Ramezani Amitis, Velayati Ali Akbar, Khorami-Sarvestani Sara, Eslamifar Ali, Mohraz Minoo, Banifazl Mohammad, Bidari-Zerehpoosh Farahnaz, Yaghmaei Farhad, McFarland Willi, Foroughi Maryam, Keyvani Hossein, Mostafavi Ehsan, Aghakhani Arezoo
Clinical Research Department, Pasteur Institute of Iran, Tehran, Iran.
Int J STD AIDS. 2013 Oct;24(10):769-74. doi: 10.1177/0956462413484457. Epub 2013 Jul 10.
Some studies have suggested that hepatitis E virus is more frequent in human immunodeficiency virus (HIV) patients and can progress to chronic infection. We aimed to determine the prevalence of hepatitis E virus antibodies and RNA in a series of 100 HIV-infected patients in Tehran, Iran, with comparison to 52 healthy HIV, hepatitis B and C-negative blood donors as controls. HIV-infected patients were also tested for hepatitis E virus-RNA. Among the HIV-infected patients, 10% had antibodies to hepatitis E virus - a finding not significantly different from the uninfected controls (11.5%). No HIV-infected patients had hepatitis E virus IgM antibodies nor did any have detectable hepatitis E virus-RNA. We found no associations between anti-hepatitis E virus IgG-seropositivity and age, sex, route of HIV acquisition, aminotransferases levels, CD4, antiretroviral therapy, hepatitis B virus and hepatitis C virus co-infection. Hepatitis E virus is relatively prevalent in our HIV-infected patients, although without evidence of chronic infection and no more common than among HIV-negative controls or the general population. For the present, we do not recommend routine screening for hepatitis E virus infection in HIV-infected patients in our moderately endemic region.
一些研究表明，戊型肝炎病毒在人类免疫缺陷病毒（HIV）感染者中更为常见，并且可能进展为慢性感染。我们旨在确定伊朗德黑兰100例HIV感染患者中戊型肝炎病毒抗体和RNA的流行情况，并与52名健康的HIV、乙肝和丙肝阴性献血者作为对照进行比较。还对HIV感染患者进行了戊型肝炎病毒RNA检测。在HIV感染患者中，10%有戊型肝炎病毒抗体——这一结果与未感染对照组（11.5%）无显著差异。没有HIV感染患者有戊型肝炎病毒IgM抗体，也没有任何患者检测到戊型肝炎病毒RNA。我们发现抗戊型肝炎病毒IgG血清阳性与年龄、性别、HIV感染途径、转氨酶水平、CD4、抗逆转录病毒治疗、乙肝病毒和丙肝病毒合并感染之间没有关联。戊型肝炎病毒在我们的HIV感染患者中相对普遍，尽管没有慢性感染的证据，也并不比HIV阴性对照组或普通人群更常见。目前，我们不建议在我们这个中度流行地区对HIV感染患者进行戊型肝炎病毒感染的常规筛查。
