Surah S, Adams R, Townsend L, Reynolds I, Kinahan J C, Keating S, Mulcahy F, Keenan E, Barry M, Lyons F
The GUIDE clinic (Department of Genito-Urinary Medicine & Infectious Diseases), St James's Hospital, Dublin, Ireland.
Int J STD AIDS. 2013 Nov;24(11):867-74. doi: 10.1177/0956462413486454. Epub 2013 Jul 23.
To investigate health-related quality of life in HIV-infected intravenous drug users registered but not engaged in HIV outpatient care (missing ≥2 outpatient appointments over 1 year or non-attendance for ≥6 months) we conducted a cross-sectional study to examine health-related quality of life of HIV-infected intravenous drug users registered for care at an inner city HIV unit. EQ-5D, SF-36, SF-6D, mood disorder, clinical and substance misuse data were collected. Mean scores and preference derived utility scores were calculated. Statistical relationships between health-related quality of life and other variables were explored using univariate and multivariate analysis. Fifty-five patients were recruited, 64% were males. The mean anxiety value was 11.44 (anxious) and mean depression score was 9.3 (borderline depressed). The mean EQ-5D utility was 0.45 (95% CI 0.35, 0.55) and mean SF-6D utility was 0.52 (95% CI 0.48, 0.55). There was no statistical relationship between HIV indices, substance misuse and EQ-5D and SF-6D utility. Anxiety and depression were significantly correlated with EQ-5D and SF-6D utility values on univariate and multivariate analysis. Health-related quality of life was reduced in this HIV-infected intravenous drug user population. Whilst hepatitis C co-infection and substance misuse did not affect health-related quality of life, anxiety and depression had a significant impact on it.
为调查在已登记但未接受艾滋病门诊治疗（在1年期间错过≥2次门诊预约或连续≥6个月未就诊）的艾滋病毒感染静脉吸毒者的健康相关生活质量，我们开展了一项横断面研究，以检查在市中心一家艾滋病毒治疗机构登记接受治疗的艾滋病毒感染静脉吸毒者的健康相关生活质量。收集了欧洲五维度健康量表（EQ - 5D）、36项简明健康调查问卷（SF - 36）、6维度健康状况量表（SF - 6D）、情绪障碍、临床及药物滥用数据。计算了平均得分和偏好衍生效用得分。使用单因素和多因素分析探讨了健康相关生活质量与其他变量之间的统计关系。招募了55名患者，其中64%为男性。平均焦虑值为11.44（焦虑状态），平均抑郁评分为9.3（临界抑郁）。平均EQ - 5D效用值为0.45（95%置信区间0.35, 0.55），平均SF - 6D效用值为0.52（95%置信区间0.48, 0.55）。艾滋病毒指标、药物滥用与EQ - 5D和SF - 6D效用之间无统计学关系。单因素和多因素分析显示，焦虑和抑郁与EQ - 5D和SF - 6D效用值显著相关。该艾滋病毒感染静脉吸毒者群体的健康相关生活质量有所下降。虽然丙型肝炎合并感染和药物滥用并未影响健康相关生活质量，但焦虑和抑郁对其有显著影响。
