Wainwright E, Sherrard J, Duncan S, Shine B, Dorrell L
Oxford Genitourinary Medicine, Oxford OX3 9DS, UK.
Int J STD AIDS. 2013 Jul;24(7):579-81. doi: 10.1177/0956462413476267. Epub 2013 Jul 8.
Hypophosphataemia with tenofovir (TDF) treatment has been well described. The role of HIV infection and of other antiretroviral (ART) agents in hypophosphataemia has received less attention. The aim of this study was to determine the prevalence of hypophosphataemia in HIV-positive adults. We measured the fasting plasma phosphate level and estimated glomerular filtration rate (eGFR) in 123 HIV-positive patients. A total of 26% had hypophosphataemia and 11% had hypophosphataemia of grades 2-4 (0.65 mmol/L or less). Hypophosphataemia of any grade was more frequent in those who were ART-treated than ART-naive (35% versus 10%; P = 0.0001). Multiple linear regression analysis showed no significant association between phosphate level and gender, TDF status, duration of ART, duration of HIV infection and eGFR. Increasing age was significantly associated with a very small rise in phosphate level. Isolated hypophosphataemia was significantly more frequent in HIV-positive subjects receiving ART than ART-naive individuals, irrespective of the drug regimen.
替诺福韦（TDF）治疗导致的低磷血症已有详尽描述。而HIV感染及其他抗逆转录病毒（ART）药物在低磷血症中的作用则较少受到关注。本研究旨在确定HIV阳性成人中低磷血症的患病率。我们测量了123例HIV阳性患者的空腹血浆磷酸盐水平及估算肾小球滤过率（eGFR）。共有26%的患者出现低磷血症，11%的患者出现2 - 4级低磷血症（0.65 mmol/L或更低）。接受ART治疗的患者中任何级别的低磷血症比未接受ART治疗的患者更常见（35%对10%；P = 0.0001）。多元线性回归分析显示，磷酸盐水平与性别、TDF使用情况、ART疗程、HIV感染时长及eGFR之间无显著关联。年龄增长与磷酸盐水平的极小升高显著相关。无论采用何种药物治疗方案，接受ART治疗的HIV阳性受试者中孤立性低磷血症的发生率显著高于未接受ART治疗的个体。
