Wypij Jackie M
Department of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Hazelwood Drive, Urbana, IL 61802, USA.
Patholog Res Int. 2013;2013:502197. doi: 10.1155/2013/502197. Epub 2013 Jul 16.
Despite advances in understanding cancer at the molecular level, timely and effective translation to clinical application of novel therapeutics in human cancer patients is lacking. Cancer drug failure is often a result of toxicity or inefficacy not predicted by preclinical models, emphasizing the need for alternative animal tumor models with improved biologic relevancy. Companion animals (dogs and cats) provide an opportunity to capitalize on an underutilized and biologically relevant translational research model which allows spontaneous disease modeling of human cancer. Head and neck squamous cell carcinoma (HNSCC) is a common cancer with a poor prognosis and limited clinical advancements in recent years. One potential novel spontaneous animal tumor model is feline oral squamous cell carcinoma (FOSCC). FOSCC and HNSCC share similar etiopathogenesis (tobacco and papillomavirus exposure) and molecular markers (EGFR, VEGF, and p53). Both human and feline SCCs share similar tumor biology, clinical outcome, treatment, and prognosis. Future clinical trials utilizing FOSCC as a tumor model may facilitate translation of preclinical cancer research for human cancer patients.
尽管在分子水平上对癌症的理解取得了进展，但新型疗法在人类癌症患者中的临床应用缺乏及时有效的转化。癌症药物研发失败往往是由于临床前模型无法预测的毒性或无效性，这凸显了对具有更高生物学相关性的替代动物肿瘤模型的需求。伴侣动物（狗和猫）提供了一个机会，可利用一种未充分利用且具有生物学相关性的转化研究模型，该模型允许对人类癌症进行自发性疾病建模。头颈部鳞状细胞癌（HNSCC）是一种常见癌症，预后较差，近年来临床进展有限。一种潜在的新型自发性动物肿瘤模型是猫口腔鳞状细胞癌（FOSCC）。FOSCC和HNSCC具有相似的病因（烟草和乳头瘤病毒暴露）和分子标志物（EGFR、VEGF和p53）。人类和猫的鳞状细胞癌在肿瘤生物学、临床结果、治疗和预后方面都有相似之处。未来利用FOSCC作为肿瘤模型的临床试验可能会促进临床前癌症研究向人类癌症患者的转化。
