Laboratory for Molecular and Cellular Biology of Cancer (LBMCC), Hôpital Kirchberg , Luxembourg , Luxembourg.
Front Oncol. 2013 Aug 20;3:202. doi: 10.3389/fonc.2013.00202. eCollection 2013.
Chemoprevention uses natural or synthetic molecules without toxic effects to prevent and/or block emergence and development of diseases including cancer. Many of these natural molecules modulate mitogenic signals involved in cell survival, apoptosis, cell cycle regulation, angiogenesis, or on processes involved in the development of metastases occur naturally, especially in fruits and vegetables bur also in non-comestible plants. Carnivorous plants including the Venus flytrap (Dionaea muscipula Solander ex Ellis) are much less investigated, but appear to contain a wealth of potent bioactive secondary metabolites. Aim of this review is to give insight into molecular mechanisms triggered by compounds isolated from these interesting plants with either therapeutic or chemopreventive potential.
化学预防使用天然或合成分子，无毒性作用，预防和/或阻断疾病（包括癌症）的发生和发展。这些天然分子中的许多调节有丝分裂信号，涉及细胞存活、细胞凋亡、细胞周期调控、血管生成或转移发生过程中的自然发生，特别是在水果和蔬菜中，但也在不可食用的植物中。肉食植物，包括维纳斯捕蝇草（Dionaea muscipula Solander ex Ellis），研究得少得多，但似乎含有丰富的有效生物活性次生代谢物。本综述的目的是深入了解从这些具有治疗或化学预防潜力的有趣植物中分离出的化合物所触发的分子机制。
