Department of Orthopaedics, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, China.
Biomed Res Int. 2013;2013:916530. doi: 10.1155/2013/916530. Epub 2013 Jul 22.
Osteoarthritis (OA) is closely associated with aging, but its underlying mechanism is unclear. Recent publications were reviewed to elucidate the connection between aging and OA. With increasing OA incidence, more senior people are facing heavy financial and social burdens. Age-related OA pathogenesis is not well understood. Recently, it has been realized that age-related changes in other tissues besides articular cartilage may also contribute to OA development. Many factors including senescence-related secretory phenotypes, chondrocytes' low reactivity to growth factors, mitochondrial dysfunction and oxidative stress, and abnormal accumulation of advanced glycation end products (AGEs) may all play key roles in the pathogenesis of age-related OA. Lately, epigenetic regulation of gene expression was recognized for its impact on age-related OA pathogenesis. Up to now, few studies have been reported about the role of miRNA and long-noncoding RNA (lncRNA) in age-related OA. Research focusing on this area may provide valuable insights into OA pathogenesis. OA-induced financial and social burdens have become an increasingly severe threat to older population. Age-related changes in noncartilage tissue should be incorporated in the understanding of OA development. Growing attention on oxidative stress and epigenetics will provide more important clues for the better understanding of the age-related OA.
骨关节炎（OA）与衰老密切相关，但发病机制尚不清楚。本研究对近年来有关衰老与 OA 关系的文献进行综述，以阐明两者之间的联系。随着 OA 发病率的增加，越来越多的老年人面临沉重的经济和社会负担。年龄相关性 OA 的发病机制尚不清楚。最近，人们认识到除关节软骨外，其他组织的年龄相关性变化也可能导致 OA 的发生。许多因素，包括与衰老相关的分泌表型、软骨细胞对生长因子反应性降低、线粒体功能障碍和氧化应激、以及晚期糖基化终产物（AGEs）的异常积累，可能在年龄相关性 OA 的发病机制中起关键作用。最近，人们认识到基因表达的表观遗传调控对年龄相关性 OA 的发病机制有重要影响。到目前为止，关于 miRNA 和长链非编码 RNA（lncRNA）在年龄相关性 OA 中的作用的研究报道较少。该领域的研究可能为 OA 的发病机制提供有价值的见解。OA 导致的经济和社会负担已成为老年人群日益严重的威胁。应将软骨外非软骨组织的年龄相关性变化纳入 OA 发病机制的认识中。对氧化应激和表观遗传学的日益关注将为更好地理解年龄相关性 OA 提供更重要的线索。
