Department of Public Health Medicine, University of KwaZulu-Natal, Durban, South Africa.
S Afr Med J. 2013 May;103(5):318-21. doi: 10.7196/samj.6414.
Cervical cancer is linked to infection of the cervix by oncogenic human papillomavirus (HPV) subtypes. The quadrivalent Gardasil vaccine (against HPV types 6, 11, 16, 18), recommended in girls 9 - 12 years of age, has been shown to be safe, immunogenic and efficacious, with minimal or no side-effects.
To demonstrate the capacity of school health teams to carry out vaccinations within a school environment.
To assess the uptake of 3 doses of the vaccine, document lessons learnt and provide recommendations for a national rollout of school-based HPV vaccination for learners.
Female learners (age 9 - 12 years) from 31 primary schools in Nongoma and Ceza districts (KwaZulu-Natal province, South Africa) were identified for inclusion in the vaccination programme. The 3 doses of vaccine were administered by existing school health teams. Education and training sessions were held with all stakeholders: provincial departments of health and education; school health teams; primary healthcare nurses; hospital doctors and nurses; private practitioners; school principals, teachers and governing bodies; parents; and community and traditional leaders.
The overall uptake of the vaccine was found to be high: 99.7%, 97.9% and 97.8% for the first, second and third doses respectively (N = 963). No adverse events were attributed to the HPV vaccine.
This project demonstrated the successful implementation of HPV vaccination among learners (ages 9 - 12 years) using school health teams.
宫颈癌与宫颈感染致癌型人乳头瘤病毒（HPV）亚型有关。四价加卫苗（针对 HPV 类型 6、11、16、18）推荐用于 9-12 岁女孩，已被证明是安全、具有免疫原性和疗效的，副作用最小或没有。
展示学校卫生团队在学校环境中进行疫苗接种的能力。
评估 3 剂疫苗的接种率，记录经验教训，并为在全国范围内开展基于学校的 HPV 疫苗接种提供建议。
在南非夸祖鲁-纳塔尔省的农戈马和切扎地区的 31 所小学中确定了年龄在 9-12 岁的女性学习者（963 人）参加疫苗接种计划。由现有的学校卫生团队接种 3 剂疫苗。对所有利益攸关方（省级卫生和教育部门、学校卫生团队、初级保健护士、医院医生和护士、私人执业者、校长、教师和管理机构、家长、社区和传统领袖）进行了教育和培训。
疫苗的总体接种率很高：第一、第二和第三剂分别为 99.7%、97.9%和 97.8%（N=963）。没有将 HPV 疫苗归因于任何不良反应。
该项目证明了使用学校卫生团队在学习者（9-12 岁）中成功实施 HPV 疫苗接种。
