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小儿急性哮喘的管理:一项基于证据的综述。

Management of acute asthma in the pediatric patient: an evidence-based review.

作者信息

Jones Brittany Pardue, Paul Audrey

机构信息

Pediatric Emergency Medicine, Icahn School of Medicine at Mount Sinai, New York, NY USA.

出版信息

Pediatr Emerg Med Pract. 2013 May;10(5):1-23; quiz 23-4.

PMID:23971269
Abstract

Asthma is the most common chronic disease of childhood, with asthma exacerbations and wheezing resulting in more than 2 million emergency department visits per year. Symptoms can vary from mild shortness of breath to fatal status asthmaticus. Given the high prevalence of asthma and its potential to progress from mild to moderate to life-threatening, it is vital for emergency clinicians to have a thorough understanding of acute asthma management. Current evidence clearly supports the use of inhaled bronchodilators and systemic steroids as first-line agents. However, in those who fail to respond to nitial therapies, a variety of adjunct therapies and interventions are available with varying degrees of evidence to support their use. This review focuses specifically on evaluation and treatment of pediatric asthma in the emergency department and reviews the current evidence for various modes of treatment.

摘要

哮喘是儿童最常见的慢性疾病,哮喘急性发作和喘息每年导致超过200万次急诊就诊。症状从轻微的呼吸急促到致命的哮喘持续状态不等。鉴于哮喘的高患病率及其从轻症发展为中度甚至危及生命的可能性,急诊临床医生全面了解急性哮喘的管理至关重要。目前的证据明确支持使用吸入性支气管扩张剂和全身性类固醇作为一线药物。然而,对于初始治疗无反应的患者,有多种辅助治疗和干预措施可供选择,且有不同程度的证据支持其使用。本综述特别关注急诊科小儿哮喘的评估和治疗,并回顾了各种治疗方式的现有证据。

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1
Management of acute asthma in the pediatric patient: an evidence-based review.小儿急性哮喘的管理:一项基于证据的综述。
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[Round Table: Severe asthma in pediatrics: treatment of acute crises].[圆桌会议:儿科重症哮喘:急性发作的治疗]
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引用本文的文献

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Emergency department treatment of asthma in children: A review.儿童哮喘的急诊科治疗:综述
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A Respiratory Therapist-Driven Asthma Pathway Reduced Hospital Length of Stay in the Pediatric Intensive Care Unit.呼吸治疗师主导的哮喘路径可缩短儿科重症监护病房的住院时间。
Respir Care. 2019 Nov;64(11):1325-1332. doi: 10.4187/respcare.06626. Epub 2019 May 14.
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Prospective study of serum and ionized magnesium pharmacokinetics in the treatment of children with severe acute asthma.
血清和离子镁药代动力学在治疗儿童重度急性哮喘中的前瞻性研究。
Eur J Clin Pharmacol. 2019 Jan;75(1):59-66. doi: 10.1007/s00228-018-2557-7. Epub 2018 Sep 26.
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Clinical pharmacokinetics of magnesium sulfate in the treatment of children with severe acute asthma.硫酸镁治疗儿童重症急性哮喘的临床药代动力学
Eur J Clin Pharmacol. 2017 Mar;73(3):325-331. doi: 10.1007/s00228-016-2165-3. Epub 2016 Dec 2.
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Evaluation of the improvement effect of laser acupuncture biostimulation in asthmatic children by exhaled inflammatory biomarker level of nitric oxide.通过呼出一氧化氮炎症生物标志物水平评估激光针刺生物刺激对哮喘儿童的改善效果。
Lasers Med Sci. 2017 Jan;32(1):53-59. doi: 10.1007/s10103-016-2082-9. Epub 2016 Oct 5.
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Asthma changes at a pediatric intensive care unit after 10 years: Observational study.10年后儿科重症监护病房的哮喘变化:观察性研究。
Ann Thorac Med. 2015 Oct-Dec;10(4):243-8. doi: 10.4103/1817-1737.165302.
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An aerosol formulation of R-salbutamol sulfate for pulmonary inhalation.一种用于肺部吸入的R-硫酸沙丁胺醇气雾剂制剂。
Acta Pharm Sin B. 2014 Feb;4(1):79-85. doi: 10.1016/j.apsb.2013.12.010. Epub 2014 Jan 18.
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Integrated traditional Chinese medicine for childhood asthma in Taiwan: a Nationwide cohort study.台湾地区儿童哮喘的中西医结合治疗:一项全国队列研究。
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