Neira L, Vermylen C, Ninane J, Doyen C, Cornu G
Department of Pediatric Hematology and Oncology, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Pediatr Hematol Oncol. 1990;7(1):89-98. doi: 10.3109/08880019009034322.
Five children with aplastic anemia (AA) were treated with Cyclosporine A (CyA) after failure or poor response to other immunosuppressive agents. A complete remission was achieved in 3 patients, a good partial response in 1, and a poor partial response in another. In 1 patient in whom a complete remission was obtained, a relapse occurred 4 months after CyA was stopped. The treatment was resumed and a complete remission was again observed. Four patients were still on treatment, and side effects were mild. CyA appeared to be an effective treatment in AA.
5例再生障碍性贫血（AA）患儿在对其他免疫抑制剂治疗无效或反应不佳后接受环孢素A（CyA）治疗。3例患者达到完全缓解，1例有良好的部分缓解，另1例部分缓解效果不佳。在1例获得完全缓解的患者中，停用CyA 4个月后复发。重新开始治疗后再次观察到完全缓解。4例患者仍在接受治疗，副作用较轻。CyA似乎是治疗AA的一种有效方法。
