Porwit A, Panayotides P, Mansson E, Osby E, Hast R, Reizenstein P
Blut. 1987 Feb;54(2):73-8. doi: 10.1007/BF00321033.
Cyclosporine A (CyA) treatment of 4 patients with severe aplastic anemia, who were ineligible for bone marrow transplantation, was carried out for periods of between 12 weeks to 20 months. A normalization of Hb and bone marrow, together with a marked improvement in WBC and platelet counts, were observed in only one of these four patients. The remission was maintained for 20 months under continuous treatment. A relapse occurred only when the patient himself interrupted treatment. No serious side effects were observed with CyA doses of 4-10 mg/kg/daily and blood concentrations of 200-400 ng/ml. No significant changes in T helper/T suppressor ratios were noted during the course of CyA treatment.
对4例不符合骨髓移植条件的严重再生障碍性贫血患者进行了环孢素A（CyA）治疗，治疗时间为12周至20个月。这4例患者中只有1例观察到血红蛋白和骨髓恢复正常，同时白细胞和血小板计数显著改善。在持续治疗下，缓解状态维持了20个月。仅在患者自行中断治疗时才出现复发。当CyA剂量为4 - 10mg/kg/每日且血药浓度为200 - 400ng/ml时，未观察到严重副作用。在CyA治疗过程中，未发现T辅助/T抑制细胞比值有显著变化。
