Research School of Biology, Bldg 134 Linnaeus Way, The Australian National University, Canberra, ACT 0200, Australia.
Curr Stem Cell Res Ther. 2013 Sep;8(5):365-9. doi: 10.2174/1574888x113089990050.
Dendritic cells (DC) are important antigen presenting cells (APC) which induce and control the adaptive immune response. In spleen alone, multiple DC subsets can be distinguished by cell surface marker phenotype. Most of these have been shown to develop from progenitors in bone marrow and to seed lymphoid and tissue sites during development. This study advances in vitro methodology for hematopoiesis of dendritic-like cells from progenitors in spleen. Since spleen progenitors undergo differentiation in vitro to produce these cells, the possibility exists that spleen represents a specific niche for differentiation of this subset. The fact that an equivalent cell subset has been shown to exist in spleen also supports that hypothesis. Studies have been directed at investigating the specific functional role of this novel subset as an APC accessible to blood-borne antigen, as well as the conditions under which hematopoiesis is initiated in spleen, and the type of progenitor involved.
树突状细胞（DC）是重要的抗原提呈细胞（APC），能诱导和控制适应性免疫反应。仅在脾脏中，就可以通过细胞表面标记表型区分多种 DC 亚群。大多数亚群已被证明起源于骨髓中的祖细胞，并在发育过程中播散到淋巴器官和组织部位。本研究旨在为从脾脏祖细胞体外生成树突样细胞的方法提供进展。由于脾脏祖细胞在体外分化产生这些细胞，因此存在这样一种可能性，即脾脏是该亚群分化的特定龛位。事实上，已有研究表明，脾脏中也存在等效的细胞亚群，这也支持了上述假说。本研究旨在探究该新型 APC 子集作为可获取血源抗原的 APC 的具体功能作用，以及启动脾脏造血的条件，以及涉及的祖细胞类型。
