Hinton Rebecca A, O'Neill Helen C
Research School of Biology, The Australian National University, Canberra, Australia
J Stem Cells. 2014;9(3):199-208.
The concept of extramedullary hematopoiesis for production of organ-specific antigen presenting cells has importance in immunity in terms of the compartmentalisation of the immune response in different tissue sites. A new and distinct dendritic-like antigen presenting cell subtype is described which is dependent on the spleen microenvironment for development. Cells arise by a unique developmental pathway distinct from other dendritic cells (DC). In particular, a self-renewing progenitor of these cells has been identified in spleen upstream of the earliest DC progenitor currently identified in bone marrow. This progenitor depends on the splenic microenvironment for maintenance and proliferation, adding further support for spleen as a site for hematopoiesis.
骨髓外造血产生器官特异性抗原呈递细胞的概念，在不同组织部位免疫反应的分区方面对免疫具有重要意义。本文描述了一种新的、独特的树突状抗原呈递细胞亚型，其发育依赖于脾脏微环境。这些细胞通过一条不同于其他树突状细胞（DC）的独特发育途径产生。特别是，在脾脏中已鉴定出这些细胞的自我更新祖细胞，其位于目前在骨髓中鉴定出的最早的DC祖细胞的上游。这种祖细胞依赖于脾脏微环境进行维持和增殖，进一步支持了脾脏作为造血部位的观点。
