Jiangsu Provincial Key Laboratory for Interventional Medical Devices, Huaiyin Institute of Technology, Huai'an 223003, China.
Colloids Surf B Biointerfaces. 2013 Dec 1;112:508-12. doi: 10.1016/j.colsurfb.2013.07.050. Epub 2013 Aug 2.
Titanium and its alloys have been widely used for blood-contacting biomedical devices; however, their blood compatibility needs to be improved. In this study, titanium surface was modified by sequential immobilization of oligo(ethylene glycol) (OEG) and 2-methacryloyloxyethyl phosphorylcholine (MPC) to improve its anticoagulation. Water contact angle results showed an excellent hydrophilic surface after the immobilization. Attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR) confirmed that OEG and MPC were successfully immobilized on titanium surface. Static platelet adhesion and APTT (activated partial thromboplastin time) experiments suggested that the anticoagulation of titanium was significantly enhanced by the immobilization of OEG and further by subsequent MPC grafting. The approach in the present study opens up a window of promising an effective and efficient method to improve the anticoagulation of blood-contact biomedical devices such as coronary stents.
钛及其合金已被广泛应用于与血液接触的生物医学设备；然而，它们的血液相容性需要得到改善。在本研究中，通过顺序固定寡聚（乙二醇）（OEG）和 2-（甲基丙烯酰氧）乙基磷酸胆碱（MPC）来修饰钛表面，以提高其抗凝血性能。水接触角结果表明，固定后表面具有优异的亲水性。衰减全反射-傅里叶变换红外光谱（ATR-FTIR）证实 OEG 和 MPC 已成功固定在钛表面上。静态血小板黏附实验和 APTT（活化部分凝血活酶时间）实验表明，OEG 的固定显著增强了钛的抗凝血性能，随后进一步接枝 MPC 可进一步提高其抗凝血性能。本研究中的方法为改善与血液接触的生物医学设备（如冠状动脉支架）的抗凝血性能提供了一种有效且高效的方法。
