Tateishi Takaharu, Kyomoto Masayuki, Kakinoki Sachiro, Yamaoka Tetsuji, Ishihara Kazuhiko
Department of Materials Engineering, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.
J Biomed Mater Res A. 2014 May;102(5):1342-9. doi: 10.1002/jbm.a.34809. Epub 2013 Jun 11.
Aromatic poly(ether ether ketone) (PEEK) is a super engineering plastic, which has good mechanical properties and is resistant to physical and chemical stimuli. We have, therefore, attempted to use PEEK in cardiovascular devices. Synthetic cardiovascular devices require both high hemocompatibility and anti-inflammatory activity in addition to the mechanical properties. We modified the PEEK surface by photoinduced and self-initiated graft polymerization with 2-methacryloyloxyethyl phosphorylcholine (MPC; PMPC-grafted PEEK) for obtaining good antithrombogenicity. Polymerization was carried out on the surface of PEEK under radiation of ultraviolet (UV) light during which we controlled monomer concentrations, temperatures, and UV intensities. The biological performance of the PMPC-grafted PEEK was examined and compared with that of unmodified PEEK. With increase in the thickness of the PMPC layer, the amount of fibrinogen adsorption decreased significantly in comparison to that in the case of unmodified PEEK. When placed in contact with human platelet-rich plasma, surface of the PMPC-grafted PEEK clearly showed inhibition of platelet adhesion and activation. Also, bacterial adhesion was reduced dramatically on the PMPC-grafted PEEK. Thus, the PMPC grafting on PEEK improved the antithrombogenicity.
芳香族聚醚醚酮（PEEK）是一种超级工程塑料，具有良好的机械性能，且耐物理和化学刺激。因此，我们尝试将PEEK用于心血管装置。合成心血管装置除了需要机械性能外，还需要高血液相容性和抗炎活性。我们通过用2-甲基丙烯酰氧乙基磷酰胆碱（MPC；接枝PMPC的PEEK）进行光诱导和自引发接枝聚合来修饰PEEK表面，以获得良好的抗血栓形成性。在紫外线（UV）辐射下于PEEK表面进行聚合反应，在此过程中我们控制单体浓度、温度和UV强度。对接枝PMPC的PEEK的生物学性能进行了检测，并与未修饰的PEEK进行比较。与未修饰的PEEK相比，随着PMPC层厚度的增加，纤维蛋白原吸附量显著降低。当与富含人血小板的血浆接触时，接枝PMPC的PEEK表面明显显示出对血小板黏附和活化的抑制作用。此外，接枝PMPC的PEEK上的细菌黏附也显著减少。因此，在PEEK上接枝PMPC改善了抗血栓形成性。
