突触前蛋白聚糖：突触发育的甜蜜组织者。
Presynaptic proteoglycans: sweet organizers of synapse development.
机构信息
Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology KAIST, Daejeon, 305-701, Korea.
出版信息
Neuron. 2013 Aug 21;79(4):609-11. doi: 10.1016/j.neuron.2013.07.048.
PMID:23972589
Abstract
Synaptic adhesion molecules control neuronal synapse development. In this issue of Neuron, Siddiqui et al. (2013) and de Wit et al. (2013) demonstrate that LRRTM4, a postsynaptic adhesion molecule, trans-synaptically interacts with presynaptic heparan sulfate proteoglycans (HSPGs) to promote synapse development.
摘要
突触黏附分子控制着神经元突触的发育。在本期《神经元》杂志中，Siddiqui 等人（2013）和 de Wit 等人（2013）证明了突触后黏附分子 LRRTM4 与突触前的硫酸乙酰肝素蛋白聚糖（HSPGs）形成跨突触相互作用，从而促进突触的发育。
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