Department of Anaesthesia and Pain Management, Royal Children's Hospital, Flemington Road, Parkville, Melbourne, Victoria 3052, Australia.
Clin Perinatol. 2013 Sep;40(3):559-73. doi: 10.1016/j.clp.2013.05.009. Epub 2013 Jul 12.
Laboratory studies have shown that general anesthetics may cause accelerated apoptosis and other adverse morphologic changes in neurons of the developing brain. The mechanism may be related to the neuronal quiescence or inactivity associated with anesthetic exposure. Few data exist on how brief anesthetic exposure may affect neurodevelopment in the newborn. Good evidence however shows that untreated pain and stress have an adverse effect on neurodevelopment, and therefore, at this stage, providing effective analgesia, sedation, and anesthesia would seem to be more important than concern over neurotoxicity.
实验室研究表明，全身麻醉可能导致发育中大脑神经元的凋亡加速和其他不良形态变化。其机制可能与麻醉暴露相关的神经元静止或不活跃有关。关于短暂的麻醉暴露如何影响新生儿的神经发育，目前的数据很少。然而，有充分证据表明，未经治疗的疼痛和应激对神经发育有不良影响，因此，在这个阶段，提供有效的镇痛、镇静和麻醉似乎比关注神经毒性更为重要。
