[亚细胞器膜作为肝脏缺血中超氧自由基的来源]
[Membranes of subcellular organelles as the source of superoxide radicals in liver ischemia].
作者信息
Vartanian L S, Rashba Iu E, Nagler L G, Zgurskiĭ A A, Oktiabr'skaia L A, Bilenko M V
出版信息
Biull Eksp Biol Med. 1990 Jun;109(6):550-2.
PMID:2397290
Abstract
O2-generation rate (Vo2-) in microsomal, mitochondrial and nuclei liver membranes was measured by ESR method, by accumulation of stable nitroxide radicals. These Vo2- values were compared with Cu, ZnSOD and MnSOD activities after 2 hours ischemia and 24 hours reoxygenation. O2- radicals generated by electron transfer chains are concluded to damage mainly during the ischemia, but not the reoxygenation.
摘要
通过稳定氮氧化物自由基的积累，采用电子自旋共振（ESR）方法测定微粒体、线粒体和肝细胞核膜中的O₂生成速率（Vo₂⁻）。将这些Vo₂⁻值与缺血2小时和复氧24小时后的铜锌超氧化物歧化酶（Cu, ZnSOD）和锰超氧化物歧化酶（MnSOD）活性进行比较。得出结论：电子传递链产生的O₂自由基主要在缺血期间造成损伤，而非复氧期间。
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