苯并(a)蒽和2,3,7,8-四氯二苯并对二恶英调节丝裂原刺激的淋巴细胞增殖
[Benz(a)anthracene and 2,3,7,8-tetrachloro dibenzo(p)dioxin modulate mitogen-stimulated proliferation of lymphocytes].
作者信息
Lozovatskiĭ A L, Ostashevskiĭ V A, Perminova O M, Kozlov V A, Tsyrlov I B
出版信息
Biull Eksp Biol Med. 1990 Jun;109(6):569-71.
The influence of benzo(a)anthracene (BA) and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) on functional properties of peripheral blood mononuclear cells (PBC) has been investigated. Incubation of mitogen-stimulated cells in the presence of xenobiotics induced high activity of benzo(a) pyrene-hydroxylase (BH) and suppressed lymphocyte blast transformation. Preincubation of unstimulated PBC with BA and TCDD caused insignificant increase of BH activity. The results show modulated effect of xenobiotics on functional properties of PBC.
研究了苯并(a)蒽(BA)和2,3,7,8-四氯二苯并对二恶英(TCDD)对外周血单个核细胞(PBC)功能特性的影响。在有外源性物质存在的情况下，对有丝分裂原刺激的细胞进行孵育，可诱导苯并(a)芘羟化酶(BH)的高活性，并抑制淋巴细胞的增殖转化。用BA和TCDD对未刺激的PBC进行预孵育，导致BH活性略有增加。结果表明外源性物质对PBC功能特性有调节作用。
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