Sim M, Gordon E B, Nicol C G
J Int Med Res. 1978;6(1):4-10. doi: 10.1177/030006057800600102.
A method for the controlled assessment of two agents for possible interaction in the treatment of endogenous depression is described. This consisted of dose-ranging the supplementary agent (oxypertine 30 mg and 60 mg daily or matching placebo) during Week 2 to Week 6 having established all patients on a therapeutic dose of imipramine during Week 1. The reported enhancement of imipramine by oxypertine was not confirmed.
本文描述了一种用于可控评估两种药物在治疗内源性抑郁症时可能存在的相互作用的方法。该方法包括在第1周让所有患者服用治疗剂量的丙咪嗪，然后在第2周~第6周对补充药物（每天30毫克和60毫克的奥昔哌汀或匹配的安慰剂）进行剂量范围研究。所报道的奥昔哌汀增强丙咪嗪疗效的作用未得到证实。
