Developmental Neurobiology Laboratory, European Neuroscience Institute, Grisebachstraße 5, 37077 Göttingen, Germany.
Curr Opin Neurobiol. 2013 Dec;23(6):974-82. doi: 10.1016/j.conb.2013.08.004. Epub 2013 Aug 23.
A remarkable feature of nervous system development is the ability of axons emerging from newly formed neurons to traverse, by cellular scale, colossal distances to appropriate targets. The earliest axons achieve this in an essentially axon-free environment, but the vast majority of axons eventually grow along a scaffold of nerve tracts created by earlier extending axons. Signal exchange between sequentially or simultaneously extending axons may well represent the predominant mode of axonal navigation, but proportionally few efforts have so far been directed at deciphering the underlying mechanisms. This review intends to provide a conceptual update on the cellular and molecular principles driving axon-axon interactions, with emphasis on those contributing to the fidelity of axonal navigation, sorting and connectivity during nerve and circuit assembly.
神经系统发育的一个显著特征是，新形成的神经元产生的轴突能够在细胞尺度上跨越巨大的距离到达适当的靶标。最早的轴突在基本上没有轴突的环境中做到了这一点，但绝大多数轴突最终是沿着由早期延伸的轴突形成的神经束生长的。顺序或同时延伸的轴突之间的信号交换很可能代表了轴突导航的主要模式，但到目前为止，很少有努力致力于破译潜在的机制。这篇综述旨在提供关于驱动轴突-轴突相互作用的细胞和分子原理的概念更新，重点是那些有助于神经和电路组装过程中轴突导航、分拣和连接的保真度的原理。
