用于药物载体的强绿光致磷光石墨烯量子点的合成。
Synthesis of strongly green-photoluminescent graphene quantum dots for drug carrier.
机构信息
Laboratory of Fiber Materials and Modern Textiles, The Growing Base for State Key Laboratory, College of Chemical and Environment Engineering, Shandong Sino-Japanese, Center for Collaborative Research of Carbon Nanomaterials, CollaborativeInnovation Center for Marine Biomass Fiber Materials and Textiles, Qingdao University, Shandong 266071, PR China.
出版信息
Colloids Surf B Biointerfaces. 2013 Dec 1;112:192-6. doi: 10.1016/j.colsurfb.2013.07.025. Epub 2013 Jul 19.
A novel approach has been developed for the preparation of strongly green-photoluminescent graphene quantum dots (GQDs-PEG) which have been surface-passivated by polyethylene glycol. The photoluminescence (PL) quantum yield of the GQDs-PEG with 400 nm excitation was about 18.8%, which was higher than other GQDs reported in the literature. More importantly, the surface-passivated PEG on GQDs can not only enhance PL intensity but also load drug by hydrogen bonding. Moreover, the high specific surface area of GQDs-PEG endowed them high loading capability (2.5 mg/mg) to carry drug. The results demonstrated that the GQDs-PEG were suitable for drug carrier and cell imaging.
一种新方法已经被开发出来，用于制备具有强烈绿色光致发光的石墨烯量子点（GQDs-PEG），这些量子点已经被聚乙二醇表面钝化。在 400nm 激发下，GQDs-PEG 的光致发光（PL）量子产率约为 18.8%，高于文献中报道的其他 GQDs。更重要的是，GQDs 表面钝化的 PEG 不仅可以增强 PL 强度，还可以通过氢键负载药物。此外，GQDs-PEG 的高比表面积赋予了它们高的载药能力（2.5mg/mg）。结果表明，GQDs-PEG 适合作为药物载体和细胞成像。
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