U.O.C. Division of Immunohematology, Transfusion Medicine and Transplant Immunology (SIMT), Regional Reference Laboratory of Transplant Immunology (LIT), Azienda Ospedaliera Universitaria (AOU), Second University of Naples, Naples, Italy.
Hum Immunol. 2013 Dec;74(12):1629-32. doi: 10.1016/j.humimm.2013.08.008. Epub 2013 Aug 20.
Recent evidences have shown that several host genetic factors influence susceptibility or protection to hepatitis C virus (HCV) infection. There are controversial data regarding the associations of human leukocyte antigens (HLA) and the clearance or progression of HCV. The aim of this study was to investigate whether particular HLA molecules were associated with HCV infection in recipients awaiting kidney transplantation considered at high-risk to infection due to protracted hemodialysis treatment. To this purpose, 301 kidney recipients with HCV infection and 1103 uninfected recipients were examined for HLA class I and II molecules. In our case-control study, HLA-A()26 is positively associated with HCV infection while HLA-A()29, -B()40 and -DRB1()01 are negatively associated with HCV infection. Multiple logistic regression analysis demonstrated that age (OR = 1.02; 95% CI = 1.01-1.04; p < 0.00), HLA-A()26, -A()29, -B()40 and -DRB1()01 [(OR = 1.54; 95% CI = 1.03-2.30; p = 0.03); (OR = 0.50; 95% CI = 0.26-0.99; p = 0.05); (OR = 0.42; 95% CI = 0.23-0, 7; p = 0.01); (OR = 0.62; 95% CI = 0.41-0, 94; p = 0.03); respectively] are independent predictors of HCV infection. Our results suggest that particular HLA molecules, as host genetic factors, may have a relationship with susceptibility or protection to HCV infection also in recipients awaiting kidney transplantation.
最近的证据表明，几种宿主遗传因素影响丙型肝炎病毒（HCV）感染的易感性或保护作用。关于人类白细胞抗原（HLA）与 HCV 清除或进展的关联存在争议数据。本研究旨在调查在因长期血液透析治疗而感染风险高的等待肾移植的患者中，特定 HLA 分子是否与 HCV 感染有关。为此，检查了 301 例 HCV 感染的肾移植受者和 1103 例未感染的受者的 HLA Ⅰ类和Ⅱ类分子。在我们的病例对照研究中，HLA-A()26 与 HCV 感染呈正相关，而 HLA-A()29、-B()40 和 -DRB1()01 与 HCV 感染呈负相关。多因素逻辑回归分析表明，年龄（OR = 1.02；95%CI = 1.01-1.04；p < 0.00）、HLA-A()26、-A()29、-B()40 和 -DRB1()01[（OR = 1.54；95%CI = 1.03-2.30；p = 0.03）；（OR = 0.50；95%CI = 0.26-0.99；p = 0.05）；（OR = 0.42；95%CI = 0.23-0.70；p = 0.01）；（OR = 0.62；95%CI = 0.41-0.94；p = 0.03）]是 HCV 感染的独立预测因子。我们的结果表明，作为宿主遗传因素的特定 HLA 分子可能与等待肾移植的患者对 HCV 感染的易感性或保护作用有关。
