Matrix and Morphogenesis Section; Laboratory of Cell and Developmental Biology; National Institute of Dental and Craniofacial Research; National Institutes of Health; Bethesda MD USA; Instructor/Lecturer at Faculty of Dentistry; Mahidol University; Rajthevi, Thailand.
Organogenesis. 2013 Jul-Sep;9(3):199-205. doi: 10.4161/org.25224. Epub 2013 Jun 6.
Our aim is to provide a summary of the field of salivary gland development and regeneration from the perspective of what is known about the function of nerves during these processes. The primary function of adult salivary glands is to produce and secrete saliva. Neuronal control of adult salivary gland function has been a focus of research ever since Pavlov's seminal experiments on salivation in dogs. Less is known about salivary gland innervation during development and how the developing nerves influence gland organogenesis and regeneration. Here, we will review what is known about the communication between the autonomic nervous system and the epithelium of the salivary glands during organogenesis. An important emerging theme is the instructive role of the nervous system on the epithelial stem/progenitor cells during development as well as regeneration after damage. We will provide a brief overview of the neuroanatomy of the salivary glands and discuss recent literature that begins to integrate neurobiology with epithelial organogenesis, which may provide paradigms for exploring these interactions in other organ systems.
我们旨在从神经在这些过程中的功能的角度概述唾液腺发育和再生领域。成人唾液腺的主要功能是产生和分泌唾液。自巴甫洛夫（Pavlov）对狗的唾液分泌进行开创性实验以来，神经对成人唾液腺功能的控制一直是研究的重点。关于发育过程中的唾液腺神经支配以及发育中的神经如何影响腺体发生和再生，人们了解得较少。在这里，我们将回顾一下在器官发生过程中自主神经系统与唾液腺上皮之间的交流。一个重要的新兴主题是神经系统在发育过程中以及损伤后再生过程中对上皮干细胞/祖细胞的指导作用。我们将简要概述唾液腺的神经解剖结构，并讨论最近的文献，这些文献开始将神经生物学与上皮器官发生结合起来，这可能为探索其他器官系统中这些相互作用提供范例。
