唾液腺发育：再生的模板。
Salivary gland development: a template for regeneration.
机构信息
Matrix and Morphogenesis Section, Laboratory of Cell and Developmental Biology, NIDCR, NIH, Bethesda, MD 20892, United States.
Matrix and Morphogenesis Section, Laboratory of Cell and Developmental Biology, NIDCR, NIH, Bethesda, MD 20892, United States.
出版信息
Semin Cell Dev Biol. 2014 Jan-Feb;25-26:52-60. doi: 10.1016/j.semcdb.2013.12.001. Epub 2013 Dec 11.
Abstract
The mammalian salivary gland develops as a highly branched structure designed to produce and secrete saliva. This review will focus on research on mouse submandibular gland development and the translation of this basic research toward therapy for patients suffering from salivary hypofunction. Here we review the most recent literature that has enabled a better understanding of the mechanisms of salivary gland development. Additionally, we discuss approaches proposed to restore salivary function using gene and cell-based therapy. Increasing our understanding of the developmental mechanisms involved during development is critical to design effective therapies for regeneration and repair of damaged glands.
摘要
哺乳动物的唾液腺发育为一种高度分支的结构，旨在产生和分泌唾液。本综述将重点介绍关于小鼠下颌下腺发育的研究，并将这些基础研究转化为治疗唾液功能低下患者的方法。在这里，我们回顾了最近的文献，这些文献使我们能够更好地理解唾液腺发育的机制。此外，我们还讨论了使用基因和细胞治疗来恢复唾液功能的方法。增加我们对发育过程中涉及的发育机制的理解对于设计有效的再生和修复受损腺体的治疗方法至关重要。
相似文献
1
Salivary gland development: a template for regeneration.
Semin Cell Dev Biol. 2014 Jan-Feb;25-26:52-60. doi: 10.1016/j.semcdb.2013.12.001. Epub 2013 Dec 11.
2
Regulatory Mechanisms Driving Salivary Gland Organogenesis.
Curr Top Dev Biol. 2015;115:111-30. doi: 10.1016/bs.ctdb.2015.07.029. Epub 2015 Oct 21.
3
Cell signaling regulation in salivary gland development.
Cell Mol Life Sci. 2021 Apr;78(7):3299-3315. doi: 10.1007/s00018-020-03741-2. Epub 2021 Jan 15.
4
Anatomy, biogenesis and regeneration of salivary glands.
Monogr Oral Sci. 2014;24:1-13. doi: 10.1159/000358776. Epub 2014 May 23.
5
Salivary gland progenitor cell biology provides a rationale for therapeutic salivary gland regeneration.
Oral Dis. 2011 Jul;17(5):445-9. doi: 10.1111/j.1601-0825.2010.01783.x. Epub 2011 Jan 11.
6
Concise Review: Salivary Gland Regeneration: Therapeutic Approaches from Stem Cells to Tissue Organoids.
Stem Cells. 2017 Jan;35(1):97-105. doi: 10.1002/stem.2455. Epub 2016 Jul 15.
7
Systems analysis of salivary gland development and disease.
Wiley Interdiscip Rev Syst Biol Med. 2010 Nov-Dec;2(6):670-82. doi: 10.1002/wsbm.94.
8
Salivary gland organogenesis.
Wiley Interdiscip Rev Dev Biol. 2012 Jan-Feb;1(1):69-82. doi: 10.1002/wdev.4. Epub 2011 Nov 17.
9
Ascl3 knockout and cell ablation models reveal complexity of salivary gland maintenance and regeneration.
Dev Biol. 2011 May 15;353(2):186-93. doi: 10.1016/j.ydbio.2011.02.025. Epub 2011 Mar 4.
10
Salivary glands: a paradigm for diversity of gland development.
Crit Rev Oral Biol Med. 1997;8(1):51-75. doi: 10.1177/10454411970080010301.
引用本文的文献
1
Inhibition of the TLR4/RAGE pathway by clearance of extracellular HMGB1 is a potential therapeutic target for radiation-damaged salivary glands.
Regen Ther. 2025 Jul 31;30:476-490. doi: 10.1016/j.reth.2025.07.004. eCollection 2025 Dec.
2
Comparative immunohistochemical characterisation of a teratoma in a domestic duck (Anas platyrhynchos) and a teratocarcinoma in a muscovy duck (Cairina moschata).
Acta Vet Scand. 2025 Apr 11;67(1):19. doi: 10.1186/s13028-025-00791-z.
3
Exosomes derived from bone marrow mesenchymal stem cells ameliorate chemotherapeutically induced damage in rats' parotid salivary gland.
Oral Maxillofac Surg. 2025 Jan 17;29(1):39. doi: 10.1007/s10006-025-01331-9.
4
Immune and non-immune mediators in the fibrosis pathogenesis of salivary gland in Sjögren's syndrome.
Front Immunol. 2024 Oct 14;15:1421436. doi: 10.3389/fimmu.2024.1421436. eCollection 2024.
5
ΔNp63 regulates Sfrp1 expression to direct salivary gland branching morphogenesis.
PLoS One. 2024 May 9;19(5):e0301082. doi: 10.1371/journal.pone.0301082. eCollection 2024.
6
Basement Membrane Mimetic Hydrogel Cooperates with Rho-Associated Protein Kinase Inhibitor to Promote the Development of Acini-Like Salivary Gland Spheroids.
Adv Nanobiomed Res. 2023 Nov;3(11). doi: 10.1002/anbr.202300088. Epub 2023 Oct 8.
7
Exploring the Cocktail Factor Approach to Generate Salivary Gland Progenitors through Co-Culture Techniques.
Tissue Eng Regen Med. 2024 Jul;21(5):749-759. doi: 10.1007/s13770-024-00632-6. Epub 2024 Mar 11.
8
Current developments and opportunities of pluripotent stem cells-based therapies for salivary gland hypofunction.
Front Cell Dev Biol. 2024 Jan 19;12:1346996. doi: 10.3389/fcell.2024.1346996. eCollection 2024.
9
Nkx2.3 transcription factor is a key regulator of mucous cell identity in salivary glands.
Dev Biol. 2024 May;509:1-10. doi: 10.1016/j.ydbio.2024.01.012. Epub 2024 Feb 2.
10
Salivary Gland Bioengineering.
Bioengineering (Basel). 2023 Dec 26;11(1):28. doi: 10.3390/bioengineering11010028.
本文引用的文献
1
Combined KIT and FGFR2b signaling regulates epithelial progenitor expansion during organogenesis.
Stem Cell Reports. 2013 Dec 12;1(6):604-19. doi: 10.1016/j.stemcr.2013.10.013. eCollection 2013.
2
Functional salivary gland regeneration by transplantation of a bioengineered organ germ.
Nat Commun. 2013;4:2498. doi: 10.1038/ncomms3498.
3
Interactions between developing nerves and salivary glands.
Organogenesis. 2013 Jul-Sep;9(3):199-205. doi: 10.4161/org.25224. Epub 2013 Jun 6.
4
Salivary gland organogenesis.
Wiley Interdiscip Rev Dev Biol. 2012 Jan-Feb;1(1):69-82. doi: 10.1002/wdev.4. Epub 2011 Nov 17.
5
Region-specific epithelial cell dynamics during branching morphogenesis.
Dev Dyn. 2013 Sep;242(9):1066-77. doi: 10.1002/dvdy.24000. Epub 2013 Aug 12.
6
Salivary gland cell differentiation and organization on micropatterned PLGA nanofiber craters.
Biomaterials. 2013 Sep;34(28):6773-84. doi: 10.1016/j.biomaterials.2013.05.061. Epub 2013 Jun 15.
7
Salisphere derived c-Kit+ cell transplantation restores tissue homeostasis in irradiated salivary gland.
Radiother Oncol. 2013 Sep;108(3):458-63. doi: 10.1016/j.radonc.2013.05.020. Epub 2013 Jun 13.
8
Paracrine effects of bone marrow soup restore organ function, regeneration, and repair in salivary glands damaged by irradiation.
PLoS One. 2013 Apr 24;8(4):e61632. doi: 10.1371/journal.pone.0061632. Print 2013.
9
Nanoparticle-mediated gene silencing confers radioprotection to salivary glands in vivo.
Mol Ther. 2013 Jun;21(6):1182-94. doi: 10.1038/mt.2013.42. Epub 2013 Mar 19.
10
An autocrine Wnt5a-Ror signaling loop mediates sympathetic target innervation.
Dev Biol. 2013 May 1;377(1):79-89. doi: 10.1016/j.ydbio.2013.02.013. Epub 2013 Feb 27.
Zotero 插件