Chen Wen-Lin, Xie Bin, Zhang Chong, Xu Kang-Li, Niu Ying-Ying, Tang Xiao-Qing, Zhang Ping, Zou Wei, Hu Bi, Tian Ying
Institute of Cognition and Nervous Systems Disease, Medical College, University of South China, Hengyang, Hunan, People's Republic of China.
Behav Pharmacol. 2013 Oct;24(7):590-7. doi: 10.1097/FBP.0b013e3283654258.
Depression is a common and debilitating mental illness and is often comorbid with anxiety disorders. Altered synaptic plasticity is considered to be an important mechanism underlying antidepressant drug action. It has been reported that hydrogen sulfide (H2S), the third gaseous transmitter, facilitates the induction of hippocampal long-term potentiation and augments synaptic neurotransmission, involved in the regulation of synaptic plasticity. The aim of this study was to clarify the antidepressant-like and anxiolytic-like effects of H2S. H2S (NaHS, 1.68 or 5.6 mg/kg, intraperitoneally, for 7 days) exerts a specific antidepressant-like effect in the forced swimming test of mice and rats and the tail suspension test of mice, and reduces the anxiety-like behaviors of both mice and rats in the elevated plus-maze test. These results reveal a unique antagonistic action of H2S in depressive-like and anxiety-like behaviors and suggest that elevating H2S signaling in the brain may represent a novel approach for the treatment of depressive and anxiety disorders.
抑郁症是一种常见且使人衰弱的精神疾病，常与焦虑症并发。突触可塑性改变被认为是抗抑郁药物作用的重要机制。据报道，硫化氢（H2S）作为第三种气体递质，可促进海马体长期增强效应的诱导并增强突触神经传递，参与突触可塑性的调节。本研究的目的是阐明H2S的抗抑郁样和抗焦虑样作用。H2S（硫氢化钠，1.68或5.6毫克/千克，腹腔注射，持续7天）在小鼠和大鼠的强迫游泳试验以及小鼠的悬尾试验中发挥特定的抗抑郁样作用，并在高架十字迷宫试验中减少小鼠和大鼠的焦虑样行为。这些结果揭示了H2S在抑郁样和焦虑样行为中的独特拮抗作用，并表明提高大脑中的H2S信号可能代表一种治疗抑郁和焦虑症的新方法。
