Dent Paul
Department of Neurosurgery; Massey Cancer Center; Virginia Commonwealth University; Richmond, VA USA.
Cancer Biol Ther. 2013 Sep;14(9):780-1. doi: 10.4161/cbt.26151. Epub 2013 Aug 15.
It has been known for many years that the protein Fas-associated death domain (FADD) is an essential protein forming the apical portion of the extrinsic apoptosis pathway that permits association of death receptors, e.g., CD95, DR4, DR5 with pro-caspases 8 and 10, thereby facilitating caspase activation (e.g., ref. 1, and references therein). It is also known that FADD can recruit other proteins to regulate NFκB and MAPK pathways which in turn can promote proliferation and cell cycle progression. In NSCLC high expression of FADD has been associated with shorter survival times and lymph node metastasis or oral cancer and worse survival, and the present manuscript in head and neck cancer demonstrates similar findings with respect to lymph node metastasis and survival.(2,3)
多年来已知，蛋白Fas相关死亡结构域（FADD）是形成外源性凋亡途径顶端部分的一种重要蛋白，该途径允许死亡受体（如CD95、DR4、DR5）与前体半胱天冬酶8和10结合，从而促进半胱天冬酶激活（例如，参考文献1及其中的参考文献）。还已知FADD可以募集其他蛋白来调节NFκB和MAPK途径，进而促进增殖和细胞周期进程。在非小细胞肺癌中，FADD的高表达与较短的生存时间以及淋巴结转移相关，或者与口腔癌和较差的生存率相关，并且本关于头颈癌的手稿在淋巴结转移和生存方面也显示了类似的结果。(2,3)
