Institute of Experimental Endocrinology, Charité University Medicine Berlin, Germany.
Curr Opin Endocrinol Diabetes Obes. 2013 Oct;20(5):441-8. doi: 10.1097/01.med.0000433066.24541.88.
To provide information on the role of the essential trace element selenium, which enables appropriate thyroid hormone synthesis, secretion, and metabolism, and to discuss supplementation with various selenium compounds, which prevent thyroid diseases such as goiter and exert beneficial effects in thyroid autoimmune diseases.
Selenium administration in both autoimmune thyroiditis (M. Hashimoto) and mild Graves' disease improves clinical scores and well-being of patients and reduces autoimmune antibody titres in several prospective, placebo-controlled supplementation studies.
Adequate nutritional supply of selenium, together with the two other essential trace elements iodine and iron, is required for a healthy thyroid during development and adolescence, as well as in the adult and aging populations.
介绍必需微量元素硒在甲状腺激素合成、分泌和代谢中的作用，讨论各种硒化合物的补充对甲状腺疾病（如甲状腺肿）的预防作用，并探讨其在甲状腺自身免疫性疾病中的有益影响。
在自身免疫性甲状腺炎（桥本甲状腺炎）和轻度格雷夫斯病中，硒的补充可改善患者的临床评分和生活质量，并降低几种前瞻性、安慰剂对照补充研究中的自身抗体滴度。
在发育和青春期、成年期和老年期，硒与另外两种必需微量元素碘和铁一起，为甲状腺的健康提供足够的营养供应。
