Department of Ophthalmology, Gunma University, School of Medicine, Maebashi, Japan.
JAMA Ophthalmol. 2013 Oct;131(10):1348-52. doi: 10.1001/jamaophthalmol.2013.4578.
Development of posterior vitreous detachment (PVD) plays an important role in vitreomacular diseases. Spectral-domain optical coherence tomography (SD-OCT) with noise reduction can visualize a posterior precortical vitreous pocket (PPVP) and classify PVD stages according to the state of the posterior wall of the PPVP.
To describe the role of the PPVP in early-stage PVDs in healthy individuals.
DESIGN, SETTING, AND PARTICIPANTS: We performed biomicroscopy and SD-OCT in the right eyes of 368 healthy volunteers (188 males and 180 females; mean [SD] age, 57.1 [19.4] years; range, 12-89 years).
The condition of the posterior wall of the PPVP was classified into stages according to the biomicroscopic findings and SD-OCT images: stage 0, no PVD with PPVP (134 eyes; mean [SD] subject age, 38.7 [16.5] years; range, 12-76 years); stage 1, paramacular PVD with PPVP (47 eyes; mean age, 55.2 [10.3] years; range, 36-77 years); stage 2, perifoveal PVD with PPVP (27 eyes; mean age, 62.0 [8.7] years; range, 46-81 years); stage 3, vitreofoveal separation with persistent attachment to the optic disc (19 eyes; mean age, 65.8 [6.2] years; range, 55-80 years; stage 3a, vitreofoveal separation with an intact posterior wall of the PPVP in 12 eyes; stage 3b, vitreofoveal separation with a defect in the posterior wall of the PPVP in 7 eyes; and stage 4, complete PVD (141 eyes; mean age, 73.2 [8.3] years; range, 48-89 years).
Ages in each PVD stage.
The posterior wall of the PPVP initially detaches at the paramacular area and extends to the perifoveal area, which results in a perifoveal PVD. A vitreofoveal detachment may develop with or without a defect in the PPVP. When the vitreous detaches from the optic disc, a complete PVD develops. An anatomical feature of the PPVP may play a role in the development of a perifoveal PVD.
后玻璃体脱离（PVD）的发展在玻璃黄斑疾病中起着重要作用。具有降噪功能的谱域光相干断层扫描（SD-OCT）可以可视化后皮质玻璃体袋（PPVP），并根据 PPVP 后壁的状态对 PVD 阶段进行分类。
描述健康个体中早期 PVD 中 PPVP 的作用。
设计、设置和参与者：我们对 368 名健康志愿者（188 名男性和 180 名女性；平均[标准差]年龄 57.1[19.4]岁；范围 12-89 岁）的右眼进行了生物显微镜检查和 SD-OCT。
根据生物显微镜检查结果和 SD-OCT 图像，将 PPVP 后壁的状况分为以下阶段：0 期，PPVP 无 PVD（134 只眼；平均[标准差]受试者年龄 38.7[16.5]岁；范围 12-76 岁）；1 期，黄斑旁 PVD 伴 PPVP（47 只眼；平均年龄 55.2[10.3]岁；范围 36-77 岁）；2 期，旁中心凹 PVD 伴 PPVP（27 只眼；平均年龄 62.0[8.7]岁；范围 46-81 岁）；3 期，玻璃体黄斑分离伴与视盘持续附着（19 只眼；平均年龄 65.8[6.2]岁；范围 55-80 岁；3a 期，12 只眼 PPVP 后壁完整的玻璃体黄斑分离；3b 期，7 只眼 PPVP 后壁有缺陷的玻璃体黄斑分离；4 期，完全 PVD（141 只眼；平均年龄 73.2[8.3]岁；范围 48-89 岁）。
各 PVD 阶段的年龄。
PPVP 的后壁最初在黄斑旁区域分离，并延伸至旁中心凹区域，导致旁中心凹 PVD。玻璃体黄斑分离可能伴有或不伴有 PPVP 缺陷。当玻璃体与视盘分离时，就会发展为完全 PVD。PPVP 的解剖特征可能在旁中心凹 PVD 的发展中起作用。
