Department of Clinical Pharmacology, Medical University of Bialystok, Waszyngtona 15A, 15-274, Bialystok, Poland,
Psychopharmacology (Berl). 2014 Jan;231(1):209-19. doi: 10.1007/s00213-013-3227-1. Epub 2013 Aug 24.
The role of histamine neurons in stress evoked cognitive impairments remains unclear. Previous research has indicated that the blockade of H(3)-type histamine receptors may improve attention and memory in naïve rodents.
The purpose of this study was to determine if ciproxifan, (cyclopropyl-(4-(3-1H-imidazol-4-yl) propyloxy) phenyl) ketone, an H(3) receptor antagonist, could alleviate cognitive deficits observed in chronically stressed rats.
Specifically, we attempted to characterize the preventive action of single dose of ciproxifan (3 mg/kg, i.p.) against an impairment caused by chronic restraint stress (2 h daily for 21 days) on recognition memory tested in an object recognition task and on the long-term memory tested in a passive avoidance test.
We found that administration of ciproxifan potently prevented deleterious effects of chronic restraint stress, when administered prior to learning, or immediately after learning, or before retrieval on both the recognition (p<0.001) and the passive avoidance behavior (p<0.001).
These data support the idea that modulation of H(3) receptors represents a novel and viable therapeutic strategy in the treatment of stress evoked cognitive impairments.
组胺神经元在应激引起的认知障碍中的作用尚不清楚。先前的研究表明，H3 型组胺受体的阻断可能会改善幼稚啮齿动物的注意力和记忆力。
本研究的目的是确定环丙基-(4-(3-1H-咪唑-4-基)丙氧基)苯基)酮，一种 H3 受体拮抗剂，是否可以减轻慢性应激大鼠观察到的认知缺陷。
具体来说，我们试图描述单次给予西普罗芬（3mg/kg，ip）对慢性束缚应激（每天 2 小时，持续 21 天）引起的认知记忆损害（在物体识别任务中进行测试）和长期记忆损害（在被动回避测试中进行测试）的预防作用。
我们发现，当在学习前、学习后立即或检索前给予西普罗芬时，它可以有效地防止慢性束缚应激的有害影响，对识别（p<0.001）和被动回避行为（p<0.001）均有影响。
这些数据支持了这样一种观点，即调节 H3 受体代表了一种治疗应激引起的认知障碍的新的可行的治疗策略。
