Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, DE-01067 Dresden, Germany.
Acta Derm Venereol. 2014 Jan;94(1):63-6. doi: 10.2340/00015555-1665.
Acquired melanocytic naevi (MN) are considered a risk factor for melanoma. Exposure to ultraviolet light (UV) is the major environmental factor for MN. UV protection is most critical in pre-school children. This 3-year interventional longitudinal study examined 395 3-year-old children attending daycare centres (DCC) in Dresden, Germany. Photo-skin type, eye and hair colour were recorded. DCC were randomly assigned to a control group and a behavioural intervention group. All children had a regular naevus check-up, including digital objective analysis with Dell'Eva-Burroni Dermoscopy Melanoma Image Processing Software (DB-MIPS) technology. Parents of children in the intervention group received additional guidance for sun-protection. The mean total MN counts of both groups at the start of the study period were 7.19 ± 4.55 (intervention) and 6.84 ± 4.63 (control), respectively. There was a significant increase in MN counts for both groups (mean 12.5 and 13.8). Subgroup analysis for skin type, eye colour, and hair colour did not demonstrate a significant influence on MN counts. The DB-MIPS integrated classifier revealed no risky lesions while analysing their patterns. Intervention did not reduce the number of newly acquired MN. MN counts in pre-school children were approximately 5 times higher than expected from previous large studies in Germany. This is the first study in pre-school children using objective digital image analysis of pigmented lesions. No atypical lesions were observed. New approaches to UV protection in pre-school children are now required.
获得性黑素细胞痣（MN）被认为是黑色素瘤的一个危险因素。紫外线（UV）暴露是 MN 的主要环境因素。UV 保护在学龄前儿童中最为关键。这项为期 3 年的干预性纵向研究对德国德累斯顿的 395 名 3 岁入托的儿童进行了研究。记录了他们的皮肤光型、眼睛和头发颜色。托儿所被随机分配到对照组和行为干预组。所有儿童都进行了定期痣检查，包括使用 Dell'Eva-Burroni Dermoscopy Melanoma Image Processing Software (DB-MIPS) 技术进行数字客观分析。干预组儿童的家长还获得了额外的防晒指导。研究开始时，两组的平均总 MN 计数分别为 7.19±4.55（干预组）和 6.84±4.63（对照组）。两组的 MN 计数均显著增加（平均增加 12.5 和 13.8）。对皮肤类型、眼睛颜色和头发颜色进行的亚组分析并没有显示 MN 计数有显著影响。使用 DB-MIPS 集成分类器分析其模式时，没有发现危险病变。干预并没有减少新获得的 MN 数量。学龄前儿童的 MN 计数比德国之前的大型研究预期的要高 5 倍左右。这是首次在学龄前儿童中使用色素性病变的客观数字图像分析进行的研究。没有观察到非典型病变。现在需要为学龄前儿童提供新的 UV 保护方法。
