Eggers H, Kuczyk M A, Schrader A J, Steffens S
Klinik für Urologie und urologische Onkologie, Medizinische Hochschule Hannover, Carl-Neubergstraße 1, 30625, Hannover, Deutschland.
Urologe A. 2013 Sep;52(9):1270-5. doi: 10.1007/s00120-013-3317-z.
Overweight presents a growing problem in our society; therefore, there is an increasing interest to understand the influence of obesity on urological forms of cancer.
In prostate cancer the development of a more aggressive phenotype seems to correlate with obesity. In renal cell cancer (RCC) obesity is both, a risk factor for occurrence -and is also associated with an improved tumour-specific survival in patients with organ-confined disease following kidney surgery as well as overall survival of patients with advanced disease receiving VEGF(R)-targeted treatment. In contrast, even though an association between body mass index (BMI) and bladder cancer has been described the role of obesity in bladder cancer remains largely unclear as published data are contradictory.
An update on currently available data focusing on the relationship between obesity and genitourinary malignancies is given in this review; however, basic research which is necessary to define the biological and metabolic effects associated with obesity and which might affect the development and progression of urological cancers, is indicated.
超重问题在我们的社会中日益凸显；因此，人们越来越关注肥胖对泌尿系统癌症的影响。
在前列腺癌中，更具侵袭性的表型发展似乎与肥胖相关。在肾细胞癌（RCC）中，肥胖既是发病的危险因素，对于接受肾脏手术的器官局限性疾病患者，肥胖还与改善肿瘤特异性生存率相关，对于接受VEGF（R）靶向治疗的晚期疾病患者，肥胖也与总体生存率相关。相比之下，尽管已经描述了体重指数（BMI）与膀胱癌之间的关联，但肥胖在膀胱癌中的作用在很大程度上仍不清楚，因为已发表的数据相互矛盾。
本综述给出了关于肥胖与泌尿生殖系统恶性肿瘤之间关系的现有数据的更新；然而，指出了基础研究的必要性，该研究对于确定与肥胖相关的生物学和代谢效应以及可能影响泌尿系统癌症发生和发展的效应是必要的。
