Guo Lei-Ming, Xi Jia-Shui, Ma Yan, Shao Lin, Nie Cui-Li, Wang Guang-Jun
Department of Pediatrics, Provincial Hospital Affiliated to Shandong University, Jinan, 250021, China.
Tumour Biol. 2014 Jan;35(1):709-13. doi: 10.1007/s13277-013-1097-0. Epub 2013 Aug 24.
Childhood acute lymphoblastic leukemia (ALL) is the leading cause of cancer-related deaths among children. Two recent genome-wide association studies and several replicated studies have provided convincing evidence that inherited genetic variation in ARID5B contributes to childhood ALL predisposition. In the present study, we performed a meta-analysis to systematically summarize the association between ARID5B genetic polymorphism and the risk for ALL. We conducted a search of case-control studies on the association of ARID5B genetic polymorphisms with susceptibility to ALL in PubMed, EMBASE, Wanfang database in China, and Chinese National Knowledge Infrastructure databases. Data from eligible studies were extracted for meta-analysis. ALL risk associated with ARID5B genetic polymorphism was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). Nine articles including 13 case-control studies were included in the present meta-analysis. We found that rs10821936 polymorphism in ARID5B gene was associated with increased risk for ALL (P < 0.0001; OR = 1.27; 95%CI, 1.17-1.37). This meta-analysis suggests that ARID5B genetic polymorphism was associated with the increased risk of ALL.
儿童急性淋巴细胞白血病（ALL）是儿童癌症相关死亡的主要原因。最近的两项全基因组关联研究和多项重复研究提供了令人信服的证据，表明ARID5B基因的遗传变异与儿童ALL易感性有关。在本研究中，我们进行了一项荟萃分析，以系统总结ARID5B基因多态性与ALL风险之间的关联。我们在中国的PubMed、EMBASE、万方数据库和中国知网数据库中搜索了关于ARID5B基因多态性与ALL易感性关联的病例对照研究。从符合条件的研究中提取数据进行荟萃分析。通过合并比值比（OR）和95%置信区间（95%CI）来估计与ARID5B基因多态性相关的ALL风险。本荟萃分析纳入了9篇文章，包括13项病例对照研究。我们发现，ARID5B基因中的rs10821936多态性与ALL风险增加相关（P < 0.0001；OR = 1.27；95%CI，1.17 - 1.37）。这项荟萃分析表明，ARID5B基因多态性与ALL风险增加有关。
