Women's Health Research Program, School of Public Health and Preventive Medicine, Monash University, 99 Commercial Road, Melbourne, Victoria, 3004, Australia,
J Cancer Surviv. 2014 Mar;8(1):1-8. doi: 10.1007/s11764-013-0306-6. Epub 2013 Aug 23.
The aim of our study was to establish the prevalence of breast pain persisting 5 years after the initial treatment of breast cancer (BC) and the relationship between those persistent symptoms and general well-being.
The study involved women from Victoria, Australia, who had survived at least 5 years from diagnosis, remained free from recurrence or new BC and completed the fifth annual follow-up questionnaire. Analysis involved both multivariable logistic and linear regression.
Of 1,205 women, 45 % reported breast pain which persisted for at least 3 months following initial treatment, and of these, 80 % reported pain persisting for at least 5 years. The factor contributing most to the likelihood of persistent breast pain was current lymphedema; however, a full multivariable model explained <10 % of the likelihood of breast pain persisting for 5 years. The presence of breast pain at 5 years was associated with only a modest reduction in general well-being.
Breast pain persisting for at least 5 years after treatment for BC is common. As the pain is largely unexplained by factors associated with the characteristics of the cancer or its treatment, the contribution of patient expectations to persistent breast pain may be considerable.
Where persistent pain occurs, referral for the management of pain and, where appropriate, lymphedema is warranted.
我们研究的目的是确定乳腺癌（BC）初始治疗后 5 年内持续存在乳房疼痛的患病率，以及这些持续存在的症状与整体健康状况之间的关系。
该研究纳入了来自澳大利亚维多利亚州的女性，这些女性在诊断后至少存活了 5 年，没有复发或新的 BC，并且完成了第五年的年度随访问卷。分析包括多变量逻辑回归和线性回归。
在 1205 名女性中，45%报告了初始治疗后至少持续 3 个月的乳房疼痛，其中 80%报告了至少持续 5 年的疼痛。导致持续性乳房疼痛可能性最大的因素是当前的淋巴水肿；然而，一个完整的多变量模型仅能解释 5 年内持续乳房疼痛的可能性 <10%。5 年后出现乳房疼痛与整体健康状况的适度下降相关。
BC 治疗后至少持续 5 年的乳房疼痛很常见。由于疼痛在很大程度上不能用与癌症特征或其治疗相关的因素来解释，因此患者的期望对持续性乳房疼痛的贡献可能相当大。
如果出现持续性疼痛，应考虑进行疼痛管理和（如适用）淋巴水肿的转诊。
