Konduri G G, Fewell J E, Taylor B J, Hill D E
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock.
Dev Pharmacol Ther. 1990;14(4):238-44.
We investigated the cardiovascular effects of chlorpromazine (CPZ) during normoxia and during alveolar hypoxia (HYP) in 9 chronically instrumented piglets aged 10-14 days. Each animal was instrumented for measurements of pulmonary and systemic arterial and left atrial pressures and pulmonary blood flow. Each piglet was studied three times: once during normoxia following infusions of normal saline (NS) and CPZ (1 mg/kg), once during established HYP (10% O2-2.5% CO2) following the infusion of NS and a third time during established HYP following the infusion of CPZ (1 mg/kg). CPZ did not alter any of the cardiovascular variables during normoxia but decreased the pulmonary arterial pressure and pulmonary vascular resistance during HYP. Thus, CPZ is a vasodilator in the pulmonary vascular bed of piglets, preconstricted by HYP.
我们研究了氯丙嗪（CPZ）对9只10 - 14日龄长期植入仪器的仔猪在常氧和肺泡缺氧（HYP）状态下心血管系统的影响。每只动物都植入了用于测量肺和体循环动脉以及左心房压力和肺血流量的仪器。每只仔猪接受三次研究：一次是在输注生理盐水（NS）和CPZ（1 mg/kg）后处于常氧状态时，一次是在输注NS后处于已建立的HYP（10% O2 - 2.5% CO2）状态时，第三次是在输注CPZ（1 mg/kg）后处于已建立的HYP状态时。CPZ在常氧状态下未改变任何心血管变量，但在HYP状态下降低了肺动脉压和肺血管阻力。因此，CPZ是一种在仔猪肺血管床中对由HYP引起的预收缩起作用的血管扩张剂。
