非精神病患者中两种短效 Z 型催眠药物的复杂睡眠行为比较。
A comparison of complex sleep behaviors with two short-acting Z-hypnosedative drugs in nonpsychotic patients.
机构信息
Department of Psychiatry, Tri-Service General Hospital, School of Medicine, National Defense Medical Center, Taipei City, Taiwan.
出版信息
Neuropsychiatr Dis Treat. 2013;9:1159-62. doi: 10.2147/NDT.S48152. Epub 2013 Aug 9.
OBJECTIVE
Complex sleep behaviors (CSBs) are classified as "parasomnias" in the International Classifcation of Sleep Disorders, Second Edition (ICSD-2). To realize the potential danger after taking two short-acting Z-hypnosedative drugs, we estimated the incidence of CSBs in nonpsychotic patients in Taiwan.
METHODS
Subjects (N = 1,220) using zolpidem or zopiclone were enrolled from the psychiatric outpatient clinics of a medical center in Taiwan over a 16-month period in 2006-2007. Subjects with zolpidem (N = 1,132) and subjects with zopiclone (N = 88) were analyzed. All subjects completed a questionnaire that included demographic data and complex sleep behaviors after taking hypnotics.
RESULTS
Among zolpidem and zopiclone users, 3.28% of patients reported incidents of somnambulism or amnesic sleep-related behavior problems. The incidence of CSBs with zolpidem and zopiclone were 3.27%, and 3.41%, respectively, which was signifcantly lower than other studies in Taiwan.
CONCLUSION
These results serve as a reminder for clinicians to make inquiries regarding any unusual performance of parasomnic activities when prescribing zolpidem or zopiclone.
目的
复杂睡眠行为（CSB）在《国际睡眠障碍分类，第二版》（ICSD-2）中被归类为“睡眠障碍”。为了认识到同时服用两种短效 Z-催眠镇静药物后的潜在危险，我们估计了在台湾非精神病患者中 CSB 的发病率。
方法
2006 年至 2007 年，我们在台湾一家医学中心的精神科门诊招募了使用唑吡坦或佐匹克隆的受试者（N=1220）。分析了使用唑吡坦（N=1132）和佐匹克隆（N=88）的受试者。所有受试者都完成了一份问卷，内容包括人口统计学数据和服用催眠药后的复杂睡眠行为。
结果
在唑吡坦和佐匹克隆使用者中，有 3.28%的患者报告出现梦游或健忘性睡眠相关行为问题。唑吡坦和佐匹克隆的 CSB 发生率分别为 3.27%和 3.41%，明显低于台湾的其他研究。
结论
这些结果提醒临床医生在开唑吡坦或佐匹克隆处方时，询问任何异常的睡眠障碍活动表现。
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