Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China.
PLoS One. 2013 Aug 16;8(8):e71003. doi: 10.1371/journal.pone.0071003. eCollection 2013.
Recent clinical studies have assessed the association of various polymorphisms on the ephreceptor tyrosinekinase-type A2 (EPHA2) with the risk for age-related cataract in populations of different ethnic/racial backgrounds, but inconsistent results have been obtained.
This meta-analysis aimed to identify if any polymorphism(s) might be commonly present in different ethnic/racial populations in association with the age-related cataract risk.
The PubMed and Web of Science databases (up to December 1, 2012) were searched for clinical studies on the association of EPHA2 polymorphisms with the risk for age-related cataract. The polymorphisms that were assessed in all eligible studies were analyzed for their association with the risk for age-related cataract using different models.
Three studies were identified, which were conducted, respectively, on white Americans in the Unites States and on Asians in Indian and China. The polymorphism, rs3754334, was the only one studied in all these three studies and was therefore the focus of this meta-analysis. No publication bias or heterogeneity was found. Our analysis results demonstrated that rs3754334 was associated with the risk of any cataracts in the recessive (OR = 1.202, 95% CI: 1.051-1.375, P = 0.007) and Codominant (OR = 1.194, 95% CI: 1.035-1.378, P = 0.015) models, but its association with cortical or nuclear phenotype of age-related cataract was not evident.
Polymorphism, rs3754334, might be a variant on the EPHA2 gene that is commonly associated with the risk for age-related cataract in different ethnical and geographical populations.
最近的临床研究评估了各种 Eph 受体酪氨酸激酶 A2（EPHA2）多态性与不同种族/人群年龄相关性白内障风险之间的关系，但结果不一致。
本荟萃分析旨在确定是否存在任何多态性与年龄相关性白内障风险相关，且在不同种族/人群中普遍存在。
检索 PubMed 和 Web of Science 数据库（截至 2012 年 12 月 1 日），以获取关于 EPHA2 多态性与年龄相关性白内障风险关联的临床研究。对所有合格研究中评估的多态性，采用不同模型分析其与年龄相关性白内障风险的关联。
共确定了 3 项研究，分别在美国的白种人、印度和中国的亚洲人中进行。这三项研究都研究了 rs3754334 多态性，因此是本荟萃分析的重点。未发现发表偏倚或异质性。我们的分析结果表明，rs3754334 与隐性（OR=1.202，95%CI：1.051-1.375，P=0.007）和共显性（OR=1.194，95%CI：1.035-1.378，P=0.015）模型中的任何白内障风险相关，但与年龄相关性白内障皮质或核表型的相关性不明显。
rs3754334 多态性可能是 EPHA2 基因上的一个常见变体，与不同种族和地理人群的年龄相关性白内障风险相关。
