Eph 受体在晶状体功能和疾病中的作用。
The role of Eph receptors in lens function and disease.
机构信息
Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.
出版信息
Sci China Life Sci. 2012 May;55(5):434-43. doi: 10.1007/s11427-012-4318-7. Epub 2012 May 27.
Abstract
Cataract is the single largest contributor to blindness in the world, with the disease having a strong genetic component. In recent years the Eph family of receptor tyrosine kinases has been identified as a key regulator in lens clarity. In this review we discuss the roles of the Eph receptors in lens biology and cataract development.
摘要
白内障是全球导致失明的首要原因，这种疾病具有很强的遗传成分。近年来，Eph 受体酪氨酸激酶家族已被确定为晶状体透明度的关键调节因子。在这篇综述中，我们讨论了 Eph 受体在晶状体生物学和白内障发生发展中的作用。
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