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载脂蛋白 E 受体 2 和 VLDL 受体对于介导 Reelin 信号通路从而调节中脑多巴胺能神经元的正常迁移和定位是必需的。

ApoER2 and VLDLr are required for mediating reelin signalling pathway for normal migration and positioning of mesencephalic dopaminergic neurons.

机构信息

Institute for Anatomy and Cell Biology, Department of Molecular Embryology, Albert-Ludwigs-Universität, Freiburg, Germany.

出版信息

PLoS One. 2013 Aug 16;8(8):e71091. doi: 10.1371/journal.pone.0071091. eCollection 2013.

DOI:10.1371/journal.pone.0071091
PMID:23976984
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3745466/
Abstract

The migration of mesencephalic dopaminergic (mDA) neurons from the subventricular zone to their final positions in the substantia nigra compacta (SNc), ventral tegmental area (VTA), and retrorubral field (RRF) is controlled by signalling from neurotrophic factors, cell adhesion molecules (CAMs) and extracellular matrix molecules (ECM). Reelin and the cytoplasmic adaptor protein Disabled-1 (Dab1) have been shown to play important roles in the migration and positioning of mDA neurons. Mice lacking Reelin and Dab1 both display phenotypes characterised by the failure of nigral mDA neurons to migrate properly. ApoER2 and VLDLr are receptors for Reelin signalling and are therefore part of the same signal transduction pathway as Dab1. Here we describe the roles of ApoER2 and VLDLr in the proper migration and positioning of mDA neurons in mice. Our results demonstrate that VLDLr- and ApoER2-mutant mice have both a reduction in and abnormal positioning of mDA neurons. This phenotype was more pronounced in VLDLr-mutant mice. Moreover, we provide evidence that ApoER2/VLDLr double-knockout mice show a phenotype comparable with the phenotypes observed for Reelin- and Dab1- mutant mice. Taken together, our results demonstrate that the Reelin receptors ApoER2 and VLDLr play essential roles in Reelin-mediated migration and positioning of mDA neurons.

摘要

中脑多巴胺能（mDA）神经元从侧脑室下区迁移到其在黑质致密部（SNc）、腹侧被盖区（VTA）和红核后区（RRF）的最终位置，受神经营养因子、细胞黏附分子（CAM）和细胞外基质分子（ECM）信号的控制。 Reelin 和细胞质衔接蛋白Disabled-1（Dab1）已被证明在 mDA 神经元的迁移和定位中发挥重要作用。缺乏 Reelin 和 Dab1 的小鼠均表现出黑质 mDA 神经元迁移异常的表型。 ApoER2 和 VLDLr 是 Reelin 信号的受体，因此是 Dab1 相同信号转导途径的一部分。在这里，我们描述了 ApoER2 和 VLDLr 在小鼠中 mDA 神经元的正常迁移和定位中的作用。我们的结果表明，VLDLr- 和 ApoER2-突变小鼠的 mDA 神经元数量减少且定位异常。VLDLr 突变小鼠的表型更为明显。此外，我们提供的证据表明，ApoER2/VLDLr 双敲除小鼠的表型与 Reelin 和 Dab1 突变小鼠观察到的表型相当。总之，我们的结果表明，Reelin 受体 ApoER2 和 VLDLr 在 Reelin 介导的 mDA 神经元迁移和定位中发挥重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/c1e438a30ae4/pone.0071091.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/f9b80bf8f7c3/pone.0071091.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/f166159ddd37/pone.0071091.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/6f0bdb00f345/pone.0071091.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/aa0e3749a069/pone.0071091.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/b6b984f7fa17/pone.0071091.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/d64efc9330c0/pone.0071091.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/a68c908e66f4/pone.0071091.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/2f23f3d45b98/pone.0071091.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/c1e438a30ae4/pone.0071091.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/f9b80bf8f7c3/pone.0071091.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/f166159ddd37/pone.0071091.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/6f0bdb00f345/pone.0071091.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/aa0e3749a069/pone.0071091.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/b6b984f7fa17/pone.0071091.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/d64efc9330c0/pone.0071091.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/a68c908e66f4/pone.0071091.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/2f23f3d45b98/pone.0071091.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63c9/3745466/c1e438a30ae4/pone.0071091.g009.jpg

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Int Rev Neurobiol. 2007;82:235-46. doi: 10.1016/S0074-7742(07)82012-5.
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4
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Transl Psychiatry. 2022 Jun 7;12(1):238. doi: 10.1038/s41398-022-02005-w.
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