Förster Eckart, Jossin Yves, Zhao Shanting, Chai Xuejun, Frotscher Michael, Goffinet André M
Institut für Anatomie und Zellbiologie, Albert-Ludwigs-Universität Freiburg, Albertstr. 17, D-79104 Freiburg, Germany.
Eur J Neurosci. 2006 Feb;23(4):901-9. doi: 10.1111/j.1460-9568.2006.04612.x.
Ten years following identification of Reelin as the product of the gene mutated in reeler mice, the signalling pathway activated by Reelin is being progressively unravelled with the identification of lipoprotein receptors as reelin receptors, of the Dab1 adapter and of some other proximal components in target cells. However, we are still a long way from understanding the action of this complex protein during brain development and maturation. The present review is organized in two parts. First, we summarize our present understanding of Reelin signalling. Then, we review critically some cell biological mechanisms for the action of Reelin based on recent studies on the development of the dentate gyrus, which has proved an extremely useful and tractable model system.
在瑞连蛋白（Reelin）被鉴定为reeler小鼠中发生突变的基因产物十年后，随着脂蛋白受体作为瑞连蛋白受体、衔接蛋白Dab1以及靶细胞中其他一些近端组分的鉴定，由瑞连蛋白激活的信号通路正逐渐被揭示。然而，我们距离理解这种复杂蛋白质在大脑发育和成熟过程中的作用仍有很长的路要走。本综述分为两部分。首先，我们总结目前对瑞连蛋白信号传导的理解。然后，我们基于最近对齿状回发育的研究，批判性地回顾一些关于瑞连蛋白作用的细胞生物学机制，齿状回已被证明是一个极其有用且易于处理的模型系统。
