Boiadzhieva N
Eksp Med Morfol. 1990;29(1):53-7.
Studies were carried out on the influence of bioshik (tinidazol), synthesised and produced by NPSK of Pharmacy at the Medical Academy on reproduction of male and female rats. The experiments were undertaken after oral administration of bioshik in two doses of 100 mg and 300 mg/kg of body mass (1/20 and 1/10 of LD50) at several stages: I stage during natal application, respectively: 1. during sexual maturation and 2. during the period of sexual maturity and II stage during prenatal administration of bioshik. The studies of the second stage were performed on 3-months old male and female rats, a generation of animals, treated with bioshik during pregnancy. The following parameters were determined: sexual receptivity, reproduction, percentage of early resorptions and mean number of normally implanted fetuses. The described data showed that there was inhibition of sexual receptivity as well as of reproduction after usage of higher doses of 300 mg/kg of body mass only natally and more manifested after application during sexual maturation. There were no data on impairement of the examined parameters for reproduction in offsprings after treatment of pregnant rats with bioshik.
对医学科学院制药厂合成生产的比奥希克（替硝唑）对雄性和雌性大鼠生殖的影响进行了研究。实验在以100毫克和300毫克/千克体重两种剂量（LD50的1/20和1/10）口服比奥希克后分几个阶段进行：第一阶段在出生时应用，分别为：1. 在性成熟期间，以及2. 在性成熟阶段；第二阶段在产前给予比奥希克。第二阶段的研究是对怀孕期接受比奥希克治疗的3个月大的雄性和雌性大鼠（一代动物）进行的。测定了以下参数：性接受能力、繁殖情况、早期吸收百分比和正常着床胎儿的平均数量。所述数据表明，仅在出生时使用300毫克/千克体重的较高剂量后，性接受能力和繁殖受到抑制，且在性成熟期间应用后更为明显。在用比奥希克治疗怀孕大鼠后，没有关于后代生殖相关参数受损的数据。
