Department of Applied Biology, Insect Biomedical Research Center, Kyoto Institute of Technology Matsugasaki, Sakyo-ku, Kyoto, 606-8585, Japan.
Am J Cancer Res. 2013 Aug 14;3(4):339-46. eCollection 2013.
Nuclear transcription factor Y (NF-Y) is an example of a transcriptional regulation factor in eukaryotes consisting of three different subunits, NF-YA, NF-YB and NF-YC, which are all necessary for formation of NF-Y complexes and binding to CCAAT boxes in promoters of its target genes. Highly conserved between human and Drosophila, NF-Y regulates transcription of various genes related to the cell cycle and various human diseases. Drosophila models have been widely used as tools for studying genetics and developmental biology and more recently for analyzing the functions of human disease genes, including those responsible for developmental and neurological disorders, cancer, cardiovascular disease and metabolic and storage diseases, as well as genes required for function of the visual, auditory and immune systems. In this review, in vivo findings from Drosophila models relevant to the roles of NF-Y in various human diseases are summarized. Recent studies have demonstrated novel contributions of dNF-Y to apoptosis and apoptosis-induced proliferation, and in photoreceptor cell differentiation during the development of the Drosophila compound eye.
核转录因子 Y（NF-Y）是真核生物转录调控因子的一个例子，由三个不同的亚基组成，NF-YA、NF-YB 和 NF-YC，它们都是形成 NF-Y 复合物和与靶基因启动子中的 CCAAT 盒结合所必需的。NF-Y 在人类和果蝇之间高度保守，调节与细胞周期和各种人类疾病相关的各种基因的转录。果蝇模型已被广泛用作研究遗传学和发育生物学的工具，最近还被用于分析人类疾病基因的功能，包括那些负责发育和神经紊乱、癌症、心血管疾病和代谢和储存疾病的基因，以及视觉、听觉和免疫系统功能所必需的基因。在这篇综述中，总结了与 NF-Y 在各种人类疾病中的作用相关的果蝇模型的体内发现。最近的研究表明，dNF-Y 对细胞凋亡和凋亡诱导的增殖以及在果蝇复眼发育过程中的光感受器细胞分化有新的贡献。
