破解神经元细胞命运密码。

Cracking the Code of Neuronal Cell Fate.

机构信息

Institute for Biomedical Research and Innovation, National Research Council (CNR-IRIB), 95126 Catania, Italy.

Section of Human Anatomy and Histology, Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy.

出版信息

Cells. 2023 Mar 30;12(7):1057. doi: 10.3390/cells12071057.

DOI:10.3390/cells12071057

PMID:37048129

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10093029/

Abstract

Transcriptional regulation is fundamental to most biological processes and reverse-engineering programs can be used to decipher the underlying programs. In this review, we describe how genomics is offering a systems biology-based perspective of the intricate and temporally coordinated transcriptional programs that control neuronal apoptosis and survival. In addition to providing a new standpoint in human pathology focused on the regulatory program, cracking the code of neuronal cell fate may offer innovative therapeutic approaches focused on downstream targets and regulatory networks. Similar to computers, where faults often arise from a software bug, neuronal fate may critically depend on its transcription program. Thus, cracking the code of neuronal life or death may help finding a patch for neurodegeneration and cancer.

摘要

转录调控对大多数生物过程至关重要，反推程序可用于破译潜在程序。在这篇综述中，我们描述了基因组学如何为控制神经元凋亡和存活的复杂且具有时间协调性的转录程序提供基于系统生物学的视角。除了为关注调控程序的人类病理学提供新的观点外，破解神经元细胞命运的密码可能为关注下游靶点和调控网络的创新治疗方法提供思路。类似于计算机，故障通常源于软件错误，神经元命运可能严重依赖于其转录程序。因此，破解神经元生死的密码可能有助于寻找神经退行性疾病和癌症的治疗方法。