Pauerstein C J, Eddy C A, Koong M K, Moore G D
Department of Obstetrics and Gynecology, University of Texas Health Science Center San Antonio 78284-7836.
Fertil Steril. 1990 Sep;54(3):522-6.
This study was undertaken to elucidate the mechanism underlying the absence of oviductal ectopic pregnancies in infraprimates. Endosalpingeal circumferential grafts were substituted for endometrium in a group of rabbits. The endosalpingeal grafts interfered with implantation as evidenced by four observations: (1) The nidation indices were lowered, (2) no implantations occurred on the grafted endosalpinx, (3) unattached blastocysts were found in animals grafted with endosalpinx, and (4) the implantation sites were significantly smaller in uterine horns containing endosalpingeal grafts. These findings suggest the presence of a factor in rabbit endosalpinx that actively suppresses ectopic implantation in the oviduct.
本研究旨在阐明低等灵长类动物输卵管内异位妊娠缺失的潜在机制。在一组兔子中，用输卵管内膜环周移植片替代子宫内膜。输卵管内膜移植片干扰了着床，这可通过以下四点观察得到证明：（1）着床指数降低；（2）移植的输卵管内膜上未发生着床；（3）在移植了输卵管内膜的动物中发现了未附着的囊胚；（4）含有输卵管内膜移植片的子宫角中的着床部位明显较小。这些发现表明，兔输卵管内膜中存在一种能积极抑制输卵管内异位着床的因子。
