Jalkanen Ville, Andersson Britt M, Bergh Anders, Ljungberg Börje, Lindahl Olof A
Department of Applied Physics and Electronics .
J Med Eng Technol. 2013 Oct;37(7):416-23. doi: 10.3109/03091902.2013.824510. Epub 2013 Aug 27.
Prostate cancer is the most common type of cancer among men worldwide. Mechanical properties of prostate tissue are promising for distinguishing prostate cancer from healthy prostate tissue. The aim was to investigate the indentation loading response of a resonance sensor for discriminating prostate cancer tissue from normal tissue. Indentation measurements were done on prostate tissue specimens ex vivo from 10 patients from radical prostatectomy. The measurement areas were analysed using standard histological methods. The stiffness parameter was linearly dependent on the loading force (average R(2 )= 0.90) and an increased loading force caused a greater stiffness contrast of prostate cancer vs normal tissue. The accuracy of the stiffness contrast was assessed by the ROC curve with the area under the curve being 0.941 for a loading force of 12.8 mN. The results are promising for the development of a resonance sensor instrument for detecting prostate cancer.
前列腺癌是全球男性中最常见的癌症类型。前列腺组织的力学特性有望用于区分前列腺癌组织与健康前列腺组织。目的是研究一种共振传感器的压痕加载响应，以区分前列腺癌组织与正常组织。对10例接受根治性前列腺切除术患者的离体前列腺组织标本进行了压痕测量。使用标准组织学方法分析测量区域。刚度参数与加载力呈线性相关（平均R(2 )= 0.90），加载力增加会导致前列腺癌组织与正常组织之间的刚度对比更大。通过ROC曲线评估刚度对比的准确性，对于12.8 mN的加载力，曲线下面积为0.941。这些结果对于开发用于检测前列腺癌的共振传感仪器很有前景。
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