Department of Applied Physics and Electronics, Umeå University, SE-90187 Umeå, Sweden.
Centre for Biomedical Engineering and Physics, Umeå University, SE-90187 Umeå, Sweden.
Sensors (Basel). 2017 Oct 26;17(11):2453. doi: 10.3390/s17112453.
Tumors in the human prostate are usually stiffer compared to surrounding non-malignant glandular tissue, and tactile resonance sensors measuring stiffness can be used to detect prostate cancer. To explore this further, we used a tactile resonance sensor system combined with a rotatable sample holder where whole surgically removed prostates could be attached to detect tumors on, and beneath, the surface ex vivo. Model studies on tissue phantoms made of silicone and porcine tissue were performed. Finally, two resected human prostate glands were studied. Embedded stiff silicone inclusions placed 4 mm under the surface could be detected in both the silicone and biological tissue models, with a sensor indentation of 0.6 mm. Areas with different amounts of prostate cancer (PCa) could be distinguished from normal tissue ( < 0.05), when the tumor was located in the anterior part, whereas small tumors located in the dorsal aspect were undetected. The study indicates that PCa may be detected in a whole resected prostate with an uneven surface and through its capsule. This is promising for the development of a clinically useful instrument to detect prostate cancer during surgery.
人类前列腺中的肿瘤通常比周围的非恶性腺体组织更硬，因此可以使用测量硬度的触觉共振传感器来检测前列腺癌。为了进一步探索这一点，我们使用了一种触觉共振传感器系统，结合一个可旋转的样品架，可以将整个手术切除的前列腺附着在上面，以检测表面下和表面上的肿瘤。我们对由硅树脂和猪组织制成的组织模型进行了研究。最后，研究了两个切除的人类前列腺。在硅树脂和生物组织模型中，都可以检测到位于表面以下 4 毫米处的嵌入式硬硅树脂嵌体，传感器压痕为 0.6 毫米。当肿瘤位于前部时，可以区分具有不同数量前列腺癌（PCa）的区域与正常组织（<0.05），而位于背部的小肿瘤则无法检测到。该研究表明，通过其包膜，可以在整个表面凹凸不平的切除前列腺中检测到 PCa。这为开发一种在手术中检测前列腺癌的临床有用仪器提供了希望。
