Marsh Rachel, Stefan Mihaela, Bansal Ravi, Hao Xuejun, Walsh B Timothy, Peterson Bradley S
Division of Child and Adolescent Psychiatry, Department of Psychiatry, the New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, New York; Eating Disorders Research Unit, Department of Psychiatry, the New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, New York.
Division of Child and Adolescent Psychiatry, Department of Psychiatry, the New York State Psychiatric Institute and the College of Physicians and Surgeons, Columbia University, New York, New York.
Biol Psychiatry. 2015 Apr 1;77(7):616-23. doi: 10.1016/j.biopsych.2013.07.017. Epub 2013 Aug 23.
The aim of this study was to examine morphometric features of the cerebral surface in adolescent and adult female subjects with bulimia nervosa (BN).
Anatomical magnetic resonance images were acquired from 34 adolescent and adult female subjects with BN and 34 healthy age-matched control subjects. We compared the groups in the morphological characteristics of their cerebral surfaces while controlling for age and illness duration.
Significant reductions of local volumes on the brain surface were detected in frontal and temporoparietal areas in the BN compared with control participants. Reductions in inferior frontal regions correlated inversely with symptom severity, age, and Stroop interference scores in the BN group.
These findings suggest that local volumes of inferior frontal regions are smaller in individuals with BN compared with healthy individuals. These reductions along the cerebral surface might contribute to functional deficits in self-regulation and to the persistence of these deficits over development in BN.
本研究旨在检查神经性贪食症（BN）青少年及成年女性受试者大脑表面的形态特征。
对34名患有BN的青少年及成年女性受试者和34名年龄匹配的健康对照受试者进行了解剖磁共振成像。我们在控制年龄和病程的同时，比较了两组受试者大脑表面的形态特征。
与对照参与者相比，BN患者额叶和颞顶叶区域的脑表面局部体积显著减小。BN组下额叶区域体积减小与症状严重程度、年龄及斯特鲁普干扰得分呈负相关。
这些发现表明，与健康个体相比，BN患者下额叶区域的局部体积较小。大脑表面的这些体积减小可能导致自我调节功能缺陷，并在BN的发育过程中持续存在这些缺陷。
