铝对大鼠脾脏免疫功能及去甲肾上腺素的影响。
Effects of Al on the splenic immune function and NE in rats.
作者信息
Hu Chongwei, Li Jing, Zhu Yanzhu, Bai Chongsheng, Zhang Jihong, Xia Shiliang, Li Yanfei
机构信息
College of Animals Science, Fujian Agricultural and Forestry University, Fuzhou 350002, China; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.
出版信息
Food Chem Toxicol. 2013 Dec;62:194-8. doi: 10.1016/j.fct.2013.08.038. Epub 2013 Aug 24.
Norepinephrine (NE) regulates the splenic immune function and it may be related to the effects of Aluminum (Al) on the splenic immune function. Here, the aim of this study was to further explore the effects of aluminum trichloride (AlCl3) on the splenic immune function and its relationship with NE. Forty male Wistar rats were orally exposed to AlCl3 (0, 64.18, 128.36 and 256.72 mg/kg BW) through drinking water for 120 days. The CD3(+), CD4(+), CD8(+) T lymphocytes, the T and B lymphocytes proliferation rates and serum NE concentration were examined. The correlation analysis between splenic immune function and NE were done. The results showed that the CD3(+), CD4(+), CD8(+) T lymphocytes and the T and B lymphocytes proliferation rates decreased and NE concentration increased in AlCl3-treated rats. NE was negatively correlated with proportions of CD3(+), CD4(+) T lymphocytes and T and B lymphocytes proliferation rates, but not correlated with CD8(+) T lymphocytes. The results suggest that AlCl3 suppresses the splenic immune function and NE plays important role in this process.
去甲肾上腺素（NE）调节脾脏免疫功能，其可能与铝（Al）对脾脏免疫功能的影响有关。在此，本研究的目的是进一步探讨三氯化铝（AlCl3）对脾脏免疫功能的影响及其与NE的关系。40只雄性Wistar大鼠通过饮水口服AlCl3（0、64.18、128.36和256.72 mg/kg体重），持续120天。检测CD3(+)、CD4(+)、CD8(+) T淋巴细胞、T和B淋巴细胞增殖率以及血清NE浓度。对脾脏免疫功能与NE之间进行相关性分析。结果显示，AlCl3处理的大鼠中，CD3(+)、CD4(+)、CD8(+) T淋巴细胞以及T和B淋巴细胞增殖率降低，而NE浓度升高。NE与CD3(+)、CD4(+) T淋巴细胞比例以及T和B淋巴细胞增殖率呈负相关，但与CD8(+) T淋巴细胞无相关性。结果表明，AlCl3抑制脾脏免疫功能，且NE在此过程中起重要作用。
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