Department of Imaging (MRI), Hospital Israelita Albert Einstein, 627, Albert Einstein Avenue, 1o.SS Bl.B 05652-900 São Paulo, Brazil.
Magn Reson Imaging. 2013 Dec;31(10):1704-8. doi: 10.1016/j.mri.2013.07.013. Epub 2013 Aug 24.
To test a magnetic resonance image (MRI) technique that uses an additional pulse in multi-echo T2* sequence that works to suppress the fat signal, in subjects with liver iron overload and concomitant presence of fat in the liver, which have been revealed as a major drawback that compromises the correct iron quantification by MRI.
Fifty magnetic resonance images of the liver (1.5T scanner) of individuals with blood ferritin increases were retrospectively reviewed for the presence of steatosis, using the sequence in and out of phase, and iron overloading, using two sequences T2 * multi-echo: one standard and other with additional fat suppression pulse. T2 * values and their standard deviations were analyzed statistically.
Our results showed that a significantly lower standard deviation of T2* values is obtained when the fat saturation pulse is applied in patients with steatosis. We found that modulation of fat signal on liver iron overload resulted in a different categorization of some patients. In one case, the patient was re-classified within normal levels of liver iron.
Our findings may contribute to a better measure of liver iron overload with relevant implications for patient treatment and care.
测试一种磁共振成像（MRI）技术，该技术在多回波 T2*序列中使用附加脉冲，以抑制脂肪信号，适用于肝脏铁过载且同时存在肝脏脂肪的患者，这是 MRI 正确量化铁含量的主要缺陷。
回顾性分析了 50 例肝脏磁共振图像（1.5T 扫描仪），这些患者的血液铁蛋白升高，使用同相位和反相位序列评估是否存在脂肪变性，并使用两种 T2多回波序列评估铁过载：一种标准序列，另一种带有附加脂肪抑制脉冲。分析 T2值及其标准差的统计学数据。
我们的结果表明，在存在脂肪变性的患者中应用脂肪饱和脉冲时，T2*值的标准偏差显著降低。我们发现，肝脏铁过载时脂肪信号的调制导致一些患者的分类不同。在一个病例中，患者重新分类为肝脏铁正常水平。
我们的发现可能有助于更好地测量肝脏铁过载，对患者的治疗和护理具有重要意义。
