Yunnan Research Center on Good Agricultural Practice for Dominant Chinese Medicinal Materials, Yunnan Agricultural University, Kunming 650201, P. R. China; College of Tobacco Science, Yunnan Agricultural University, Kunming 650201, P. R. China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China.
Fitoterapia. 2013 Dec;91:82-86. doi: 10.1016/j.fitote.2013.08.011. Epub 2013 Aug 23.
Five new 8-9' linked neolignans conchigeranals A-E (1-5), together with three known compounds galanganal (6), galanganols A (7) and B (8), were isolated from the whole plant of Alpinia conchigera. Their structures were established by spectroscopic analysis, including 2D-NMR spectroscopic techniques. Cytotoxicities of compounds 1-8 were tested against two cancer cell lines A549 and Hela. Results showed that 4, 5, 7 and 8 exhibited cytotoxicity against A549 with the IC50 values of 12.36, 9.72, 10.26, 13.05 μg/ml, respectively, and 1-8 against Hela with the IC50 values from 1.53 to 5.29 μg/ml.
从益智的全株植物中分离得到了五个新的 8-9' 连接的新木脂素 conchigeranals A-E（1-5），以及三个已知化合物 galanganal（6）、galanganols A（7）和 B（8）。通过光谱分析，包括 2D-NMR 光谱技术，确定了它们的结构。测试了化合物 1-8 对两种癌细胞系 A549 和 Hela 的细胞毒性。结果表明，化合物 4、5、7 和 8 对 A549 的细胞毒性分别为 12.36、9.72、10.26 和 13.05μg/ml，化合物 1-8 对 Hela 的细胞毒性为 1.53-5.29μg/ml。
