来自高良姜根茎的新型细胞毒性二芳基庚烷类化合物。

New cytotoxic diarylheptanoids from the rhizomes of Alpinia officinarum Hance.

作者信息

Liu Dan, Liu Yan-Wen, Guan Fu-Qin, Liang Jing-Yu

机构信息

Hubei Key Laboratory of Resource Science and Chemistry in Chinese Medicine, Hubei university of Chinese Medicine, Wuhan 430061, China.

Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing 210014, China.

出版信息

Fitoterapia. 2014 Jul;96:76-80. doi: 10.1016/j.fitote.2014.04.008. Epub 2014 Apr 18.

DOI:10.1016/j.fitote.2014.04.008

PMID:24752140

Abstract

Two new dimeric diarylheptanoids, named Alpinin C (1) and D (2), a new natural product of diarylheptanoid (3) along with three known diarylheptanoids (4-6) were isolated from the rhizomes of Alpinia officinarum Hance. Their structures were elucidated based on extensive spectroscopic analyses (1D and 2D NMR, HRTOFMS, IR). The isolated compounds were evaluated for their cytotoxicity against human tumor cell lines HepG2, MCF-7, T98G and B16-F10. Compound 1 showed selective cytotoxicity against cell lines of MCF-7 and T98G, while compound 6 showed significant cytotoxicity to the all tested tumor cell lines with IC50 in the range from 8.46 to 22.68 μmol/L.

摘要

从高良姜的根茎中分离出两种新的二聚体二芳基庚烷类化合物，命名为山姜素C（1）和D（2），一种新的二芳基庚烷类天然产物（3）以及三种已知的二芳基庚烷类化合物（4 - 6）。基于广泛的光谱分析（一维和二维核磁共振、高分辨飞行时间质谱、红外光谱）阐明了它们的结构。对分离得到的化合物进行了针对人肿瘤细胞系HepG2、MCF - 7、T98G和B16 - F10的细胞毒性评估。化合物1对MCF - 7和T98G细胞系表现出选择性细胞毒性，而化合物6对所有测试的肿瘤细胞系均表现出显著的细胞毒性，IC50范围为8.46至22.68 μmol/L。